Development of micrRNA-targeting cancer prevention

黄酮类化合物是一种癌症预防剂，可诱导前列腺癌细胞的生长停滞、G1期阻滞以及E2 F1和E2 F3的减少，而E2 F1和E2 F3是G1/S进展的关键。黄酮还诱导miR-34 a，其调节E2 F1和E2 F3的表达。抑制miR-34 a可抑制黄酮诱导的G1期阻滞和E2 F1、E2 F3的减少。这些结果提出了癌症预防剂通过诱导microRNA抑制细胞增殖的可能性。

Flavone, which is known as a cancer preventive agent, induced growth inhibiton, G1 arrest and the decrease of the E2F1 and E2F3, which act for G1/S progression, in prostate cancer cells. Flavone also induced miR-34a, which regulates the expression of E2F1 and E2F3. Furthermore, the inhibition of miR-34a suppressed the G1 arrest and decrease of the E2F1 and E2F3 by the treatment of flavone. These results raise a possibility that cancer preventive agents inhibit the cell proliferation through the in duction of microRNAs.