Nuclear receptors as therapeutic targets for diabeticnephropathy.

在糖尿病肾病的发展过程中，肾细胞肥大在疾病的初始过程中起重要作用，慢性炎症进一步促进了疾病的发展。核受体调节剂可能会改善这些病理过程。过氧化物酶体增殖物激活受体δ和肝X受体激动剂通过改善炎症而发挥治疗潜力。维甲酸X受体(RXR)拮抗剂通过纠正细胞周期异常和细胞肥大而显示出治疗潜力。核受体调节剂对糖尿病肾病的治疗是有益的。

In the development of diabetic nephropathy, the hypertrophy of renal cells is important for the initial disease process and chronic inflammation further promotes the progression of the disease. Modulator for nuclear receptors may improve these pathological processes. Peroxisome proliferator-activated receptor (PPAR)-δand Liver X receptor (LXR) agonists exerted therapeutic potential by improving inflammation. Retinoid X receptor (RXR) antagonist demonstrated therapeutic potential by correcting cell-cycle abnormalities and cellular hypertrophy. Modulators for nuclear receptors are beneficial for the treatment of diabetic nephropathy.