Elucidation on the molecular mechanisms of the carcinogenesis and malignant transformation of oral cancer via DeltaNp63-mediated epithelial-mesenchymal transition

DeltaNp63介导的上皮间质转化阐明口腔癌发生和恶变的分子机制

• 批准号: 26861729
• 负责人: Matsubara Ryota
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26861729/
• 关键词: ΔNp63; 口腔扁平上皮癌; 上皮-間葉転換（EMT）; KLK6; miR-205; 上皮－間葉転換（EMT）; 浸潤・転移

项目成果

Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.

• DOI: 10.3892/or.2015.3838
• 发表时间: 2015-05
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Jinno T;Kawano S;Maruse Y;Matsubara R;Goto Y;Sakamoto T;Hashiguchi Y;Kaneko N;Tanaka H;Kitamura R;Toyoshima T;Jinno A;Moriyama M;Oobu K;Kiyoshima T;Nakamura S
• 通讯作者: Nakamura S

Clinical evaluation of oral squamous cell carcinoma patients with the synchronous second cancer detected by upper gastrointestinal fiberscopy

上消化道纤维镜检出口腔鳞癌并发继发癌的临床评价

• 发表时间: 2016
• 作者: Ryota Matsubara;Shintaro Kawano;Teppei Jinno;Yasuyuki Maruse;Naoki Kaneko;Taiki Sakamoto;Yuma Hashiguchi;Kazunari Oobu;and Seiji Nakamura
• 通讯作者: and Seiji Nakamura

8.Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor: a case report and literature review

8.同时产生甲状旁腺激素相关蛋白和粒细胞集落刺激因子的舌鳞状细胞癌1例报道并文献复习

• 发表时间: 2016
• 期刊: World Journal of Surgical Oncology
• 影响因子: 3.2
• 作者: Naoki Kaneko;Shintaro Kawano;Ryota Matsubara;Yuichi Goto;Teppei Jinno;Yasuyuki Maruse;Taiki Sakamoto;Yuma Hashiguchi;Masakazu Iida;Seiji Nakamura
• 通讯作者: Seiji Nakamura

6.Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype

6.ΔNp63下调可能通过诱导间充质表型参与口腔鳞状细胞癌的侵袭和转移

• 发表时间: 2014
• 期刊: Clinical and Experimental Metastasis
• 影响因子: 4
• 作者: Yuichi Goto;Shintaro Kawano;Ryota Matsubara;Takahiro Kiyosue;Mitsuhiro Hirano;Teppei Jinnno;Yasuyuki Maruse;Takeshi Toyoshima;Ryoji Kitamura Hideaki Tanaka;Kazunari Oobu;Seiji Nakamura
• 通讯作者: Seiji Nakamura

蝶形骨に転移をきたした下顎骨中心性扁平上皮癌への対応

下颌骨中央鳞状细胞癌转移至蝶骨的治疗

• 发表时间: 2017
• 作者: Nakagawa Y;Nakayama H;Nagata M;Yoshida R;Kawahara K;Hirosue A;Tanaka T;Yuno A;Matsuoka Y;Kojima T;Yoshitake Y;Hiraki A;Shinohara M.;松原良太
• 通讯作者: 松原良太