Comprehensive Studies toward Synthesis of Glycoproteins
Comprehensive Studies toward Synthesis of Glycoproteins
批准号:
17GS0420
负责人:
ITO Yukishige
金额:
$219.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Creative Scientific Research
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
·Analysis of intracellular glycoprotein processing was conducted by using synthetic high-mannose-type glycans and their derivatives.·Thioester forming reaction and amino-protecting group were developed and applied to syntheses of glycoproteins and dendrimers.A novel efficient reaction which utilize an ultra-high pressure was developed。·Syntheses of glycoproteins which carry complex-type glycans were achieved.The most significant among them is the synthesis of erythmpoietin(EPO),a medically important glycoprotein。体外assay clarified that its cell-proliferating activity was almost indistinguishable with native EPO.
英文摘要
・Analysis of intracellular glycoprotein processing was conducted by using synthetic high-mannose-type glycans and their derivatives.・Thioester forming reaction and amino-protecting group were developed and applied to syntheses of glycoproteins and dendrimers. A novel efficient reaction which utilize an ultra-high pressure was developed.・Syntheses of glycoproteins which carry complex-type glycans were achieved. The most significant among them is the synthesis of erythmpoietin (EPO), a medically important glycoprotein. In vitro assay clarified that its cell-proliferating activity was almost indistinguishable with native EPO.
期刊论文(159)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1021/ja077570k
发表时间:
2008-02-13
期刊:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子:
15
作者:
[Totani, Kiichiro, Ihara, Yoshito, Ito, Yukishige]
通讯作者:
Ito, Yukishige
DOI:
10.1002/chem.200600179
发表时间:
2007-01
期刊:
Chemistry
影响因子:
--
作者:
[Naoki Yamamoto;Ayumi Takayanagi;Ayako Yoshino;T. Sakakibara;Y. Kajihara]
通讯作者:
Naoki Yamamoto;Ayumi Takayanagi;Ayako Yoshino;T. Sakakibara;Y. Kajihara
First chemical synthesis of triglucosylated tetradecasaccharide (Gle3Man9GlcNAc2), a common precursor of asparagine-linked oligosaccharides.
首次化学合成三葡萄糖基化十四糖 (Gle3Man9GlcNAc2),这是天冬酰胺连接寡糖的常见前体。
DOI:
--
发表时间:
2005
期刊:
Tetrahedron Lett. 46
影响因子:
--
作者:
[I.Matsuo, T.Kashiwagi, K.Totani, Y.Ito]
通讯作者:
Y.Ito
Increased expression of protein C-mannosylation in the aortic vessels of siabetic Zucker rats.
糖尿病 Zucker 大鼠主动脉血管中蛋白质 C-甘露糖基化表达增加。
DOI:
--
发表时间:
2005
期刊:
Glycobiology 15
影响因子:
--
作者:
[Y.Ihara, S.Manabe, M.Kanda, H.Kawano, T.Nakayama, I.Sekine, T.Kondo, Y.Ito]
通讯作者:
Y.Ito
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[大畠悟郎, 神澤悠輔, 齋藤伸吾, 溝口幸司, 中山正昭, 梶原康宏]
通讯作者:
梶原康宏
共 128 条
Organic Synthesis of Glycoprotein Structural Motifs
-
批准号:13480191
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.12万
-
财政年份:2001
-
负责人:ITO Yukishige
-
依托单位:
Synthesis of Glycoconjugate Derived Glycans as Molecular Probes
-
批准号:08457590
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1996
-
负责人:ITO Yukishige
-
依托单位:
海外基金