Comprehensive Studies toward Synthesis of Glycoproteins
Comprehensive Studies toward Synthesis of Glycoproteins
批准号:
17GS0420
负责人:
ITO Yukishige
金额:
$219.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Creative Scientific Research
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
对内源性糖蛋白处理的分析是由使用合成高甘露糖型糖及其衍生物进行的。硫酯形成反应和氨基保护组已经开发和应用于糖蛋白质和皮肤修饰剂合成。一种新的有效反应,它利用了一种超高压的压力。glycoproteins的合成,即携带复合体型glycans已实现。它们中间最有意义的物质是红细胞素(EPO)的综合体,一种医学上重要的糖蛋白质。体外测定是明确的,因为它的细胞增殖活动几乎可以被原生EPO所独立。
英文摘要
・Analysis of intracellular glycoprotein processing was conducted by using synthetic high-mannose-type glycans and their derivatives.・Thioester forming reaction and amino-protecting group were developed and applied to syntheses of glycoproteins and dendrimers. A novel efficient reaction which utilize an ultra-high pressure was developed.・Syntheses of glycoproteins which carry complex-type glycans were achieved. The most significant among them is the synthesis of erythmpoietin (EPO), a medically important glycoprotein. In vitro assay clarified that its cell-proliferating activity was almost indistinguishable with native EPO.
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DOI:
10.1021/ja077570k
发表时间:
2008-02-13
期刊:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子:
15
作者:
[Totani, Kiichiro, Ihara, Yoshito, Ito, Yukishige]
通讯作者:
Ito, Yukishige
DOI:
10.1002/chem.200600179
发表时间:
2007-01
期刊:
Chemistry
影响因子:
--
作者:
[Naoki Yamamoto;Ayumi Takayanagi;Ayako Yoshino;T. Sakakibara;Y. Kajihara]
通讯作者:
Naoki Yamamoto;Ayumi Takayanagi;Ayako Yoshino;T. Sakakibara;Y. Kajihara
First chemical synthesis of triglucosylated tetradecasaccharide (Gle3Man9GlcNAc2), a common precursor of asparagine-linked oligosaccharides.
首次化学合成三葡萄糖基化十四糖 (Gle3Man9GlcNAc2),这是天冬酰胺连接寡糖的常见前体。
DOI:
--
发表时间:
2005
期刊:
Tetrahedron Lett. 46
影响因子:
--
作者:
[I.Matsuo, T.Kashiwagi, K.Totani, Y.Ito]
通讯作者:
Y.Ito
Increased expression of protein C-mannosylation in the aortic vessels of siabetic Zucker rats.
糖尿病 Zucker 大鼠主动脉血管中蛋白质 C-甘露糖基化表达增加。
DOI:
--
发表时间:
2005
期刊:
Glycobiology 15
影响因子:
--
作者:
[Y.Ihara, S.Manabe, M.Kanda, H.Kawano, T.Nakayama, I.Sekine, T.Kondo, Y.Ito]
通讯作者:
Y.Ito
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[大畠悟郎, 神澤悠輔, 齋藤伸吾, 溝口幸司, 中山正昭, 梶原康宏]
通讯作者:
梶原康宏
共 128 条
Organic Synthesis of Glycoprotein Structural Motifs
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批准号:13480191
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.12万
-
财政年份:2001
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负责人:ITO Yukishige
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依托单位:
Synthesis of Glycoconjugate Derived Glycans as Molecular Probes
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批准号:08457590
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.74万
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财政年份:1996
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负责人:ITO Yukishige
-
依托单位:
海外基金