Role of mammalian-specific genes related to genomic imprinting in mammalian development and evolution

寿司反转录转座子衍生基因（Sirh家族基因）是哺乳动物特有的基因。其中，我们之前报道过Peg10和Peg11/Rtl1在胎盘形成和功能中发挥重要作用。在本项目中，我们制作了每个基因的敲除小鼠，并证明Sirh7在植入和妊娠以及胎盘形成方面具有哺乳动物特有的功能。我们的系统分析表明，其他Sirh基因也具有这样的功能。

Sushi-ichi retrotransposon-derived genes (Sirh family genes) are mammalian-specific genes. Among them, we have previously reported that Peg10 and Peg11/Rtl1 play essential roles in placenta formation and function. In this project, we have produced knockout mice of each gene and demonstrated that Sirh7 has mammalian-specific functions concerning implantation and pregnancy as well as placenta formation. Our systematic analysis suggests that other Sirh genes also have such functions.