A new tracer development for positron emission tomographic imaging with an isotope62Zn containing porphyrins
A new tracer development for positron emission tomographic imaging with an isotope62Zn containing porphyrins
批准号:
23659576
负责人:
MATSUI Hirofumi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
点击翻译按钮获取中文摘要
英文摘要
To develop a new tracer for positron emission tomography imaging(PET), we newly synthesized 62Zn containing porphyrin derivatives which have been reported to be accumulated in neoplastic cells. We investigated the efficacy of our Zn-porphyrins for tumor-area diagnosis with cancer cell-transplanted mice. These tracers were accumulated in the tumor tissue, as well as the liver and the spleen: both organs play important role for heme metabolisms. According to these results, 62Zn-porphyrin is suggested to be one of candidates for a tumor tracer in PET imaging.
期刊论文(22)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
がん浸潤に対するミトコンドリア由来活性酸素の関与
线粒体衍生的活性氧参与癌症侵袭
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[田村磨聖, 松井裕史, 馬嶋秀行, 兵頭一之介]
通讯作者:
兵頭一之介
がん集積ポルフィリンの放射線イメージング
癌症累积卟啉的放射成像
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Baba, K. & Nitta, R., 松井裕史]
通讯作者:
松井裕史
DOI:
10.3164/jcbn.12-41
发表时间:
2012-11
期刊:
Journal of clinical biochemistry and nutrition
影响因子:
2.4
作者:
[Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I]
通讯作者:
Hyodo I
Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line
线粒体产生的活性氧对 X 射线诱导的人肝癌细胞系细胞凋亡的作用
DOI:
--
发表时间:
2012
期刊:
HLE, Free radical research
影响因子:
--
作者:
[Indo HP, Inanami O, Koumura T, Suenaga S, Hsiu-Chuan Yen, Kakinuma S, Matsumoto K, Nakanishi I, St Clair W, St Clair DK, Matsui H, Cornette R, Gusev O, Okuda T, Nakagawa Y, Ozawa T and Majima HJ]
通讯作者:
Ozawa T and Majima HJ
DOI:
10.1016/j.bcp.2012.09.016
发表时间:
2012-12
期刊:
Biochemical pharmacology
影响因子:
5.8
作者:
[Shintaro Suemasu;N. Yamakawa;T. Ishihara;Teita Asano;Kayoko Tahara;Ken-ichiro Tanaka;H. Matsui;Yoshinari Okamoto;M. Otsuka;K. Takeuchi;Hidekazu Suzuki;T. Mizushima]
通讯作者:
Shintaro Suemasu;N. Yamakawa;T. Ishihara;Teita Asano;Kayoko Tahara;Ken-ichiro Tanaka;H. Matsui;Yoshinari Okamoto;M. Otsuka;K. Takeuchi;Hidekazu Suzuki;T. Mizushima
共 19 条
Detection of circulationg tumor cells with porphyrin fluorescense
-
批准号:15K15188
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2015
-
负责人:MATSUI Hirofumi
-
依托单位:
海外基金