Analysis of phospholipid metabolic enzymes in thyroid tumors

甲状腺肿瘤中磷脂代谢酶的分析

• 批准号: 23701036
• 负责人: KOFUJI Satoshi
• 金额: $ 2.83万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701036/
• 关键词: リン脂質; 脂質; 遺伝子改変動物

Phosphatidylinositols are one of the important lipids composed of cell membranes, and there are eight species. Their abundance is very little, but they function as a signal molecule, and the dysfunction of the production or degradation of each species causes critical diseases, so they have been extensively researched. In this study, we analyzed the physiological roles by creating knockout mice for their enzymes. We found that the enzymes had an important role in thyroid tumors.

磷脂酰肌醇是构成细胞膜的重要脂质之一，共有8种。它们的丰度很少，但它们的功能是信号分子，每个物种的生产或降解功能障碍会导致危重疾病，因此它们得到了广泛的研究。在这项研究中，我们通过为它们的酶创建基因敲除小鼠来分析它们的生理作用。我们发现这些酶在甲状腺肿瘤中起着重要作用。

项目成果

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

• DOI: 10.1073/pnas.1213212110
• 发表时间: 2013-01
• 期刊: Proceedings of the National Academy of Sciences
• 作者: S. Takasuga;Y. Horie;J. Sasaki;G. Sun-Wada;N. Kawamura;Ryota Iizuka;K. Mizuno;S. Eguchi;Satoshi Kofuji;H. Kimura;Masakazu Yamazaki;Chihoko Horie;Eri Odanaga;Yoshiko Sato;S. Chida;K. Kontani;A. Harada;T. Katada;A. Suzuki;Y. Wada;H. Ohnishi;Takehiko Sasaki

Ship1 deletion enhances ROS production and decreases survival of the S.aureus infected mice

Ship1 缺失增强 ROS 产生并降低金黄色葡萄球菌感染小鼠的存活率

• 发表时间: 2012
• 期刊: Akita Journal of Medicine
• 作者: Chida S;Itoh R;Kofuji S;Eguchi S;Takasuga S;Sasaki J;Sasaki T
• 通讯作者: Sasaki T

秋田大学大学院医学系研究科微生物学講座

秋田大学大学院医学研究科微生物学系

SHIP1 deletion enhances ROS production and decreases survival of the S.aureus infected mice.

SHIP1 缺失会增强 ROS 的产生并降低金黄色葡萄球菌感染小鼠的存活率。

• 发表时间: 2012
• 期刊: Akita Journal of Medicine
• 作者: Matsui H;Kaneko T;Hyodo I;Chida S et al.
• 通讯作者: Chida S et al.