Gold-Catalyzed Late-Stage Diversification of Prenylated Pharmaceuticals and Biomolecules with Acetylene Gas

本研究以高取代烯烃和乙炔为原料，在金(I)催化下合成1,3-丁二烯。主要的焦点将放在该反应的立体选择性上，因为在生成的二烯产物中可能有不同的双键几何形状。这种选择性是通过新颖的，立体要求高的金(I)配合物来实现的，它应该只允许形成单一的非对映体。通过这样的反应，在许多不同的天然产物和药物中存在的戊烯基残基可以扩展为1,3-丁二烯。该反应可用于药物的后期功能化，以寻找更有效的衍生物，也将进行研究。

The aim of the research project is the synthesis of 1,3-butadienes starting from highly substituted olefins and acetylene under gold(I) catalysis. The main focus will be on the stereoselectivity of this reaction, since different double bond geometries are possible in the resulting diene products. This selectivity is to be achieved by novel, sterically demanding gold(I) complexes, which should only allow the formation of a single diastereomer. By such a reaction, prenyl residues, which occur in many different natural products and pharmaceuticals, could be extended to 1,3-butadienes. This reaction could be useful for late-stage functionalization of pharmaceuticals in the search for more potent derivatives and will also be investigated.