Regulation of immune cell populations and immune pathways by sex hormones

性激素对免疫细胞群和免疫途径的调节

• 批准号: 513826600
• 负责人: Professor Dr. Marcus Altfeld
• 金额: --
• 依托单位: Bernhard-Nocht-Institut für Tropenmedizin (BNITM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/513826600?language=en
• 关键词: Regulation; immune; cell; populations; pathways

Immune responses differ between females and males. Females mount stronger immune responses against pathogens, vaccines, and malignancies. Enhanced immune responsiveness in females, however, comes at a cost, including significantly higher incidences of autoimmune diseases. Despite these well-established sex differences in malignancies, infectious and autoimmune diseases, the underlying biological mechanisms have not been systematically examined. Increasing evidence suggests that common biological pathways regulating immune cell functions are involved in sex-specific differences in immunity, and that these immune pathways can be regulated by sex hormones. The principal aim of the current proposal is to determine the impact of sex hormones on immune cells and pathways, testing the hypothesis that testosterone regulates inflammatory immune responses. We will use an integrated approach combining longitudinal samples from a human transgender cohort (hTGC) and mouse models to determine the impact of sex hormones on inflammatory pathways in innate and adaptive immune cells, using single cell multiomics NGS approaches.

女性和男性的免疫反应是不同的。女性对病原体、疫苗和恶性肿瘤的免疫反应更强。然而，增强女性的免疫反应性是有代价的，包括显著增加自身免疫性疾病的发病率。尽管在恶性肿瘤、传染病和自身免疫性疾病中存在这些公认的性别差异，但其潜在的生物学机制尚未得到系统的研究。越来越多的证据表明，调节免疫细胞功能的常见生物途径与特定性别的免疫差异有关，而且这些免疫途径可以受性激素调节。目前这项提议的主要目的是确定性激素对免疫细胞和免疫途径的影响，验证睾丸激素调节炎症免疫反应的假设。我们将使用一种综合的方法，结合来自人类变性人队列(HTGC)的纵向样本和小鼠模型，使用单细胞多组学NGS方法来确定性激素对先天和获得性免疫细胞炎症途径的影响。