TRR 386: HYP*MOL – Hyperpolarization in molecular systems

TRR 386：HYP*MOL â 分子系统中的超极化

• 批准号: 514664767
• 金额: --
• 依托单位: Universität Augsburg
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/514664767?language=en
• 关键词: TRR; 386; HYP; MOL; Hyperpolarization

Electrons and many atomic nuclei carry not only electric charge, but also a magnetic moment called “spin”. The controlled realization of a transient spin order of electrons or magnetic nuclei, i.e., of hyperpolarization, in molecular systems is expected to have a major impact in three research areas of chemistry and physics, namely magnetic resonance, spintronics and spin-chemistry with implications towards practical applications for example in medicine, multifunctional electronics, or high-yield catalysis. The CRC HYP*MOL will contribute to the fundamental understanding of generation of electronic and nuclear spin hyperpolarization, its transport through molecular structures and its control. To that end, HYP*MOL will bring the fields of magnetic resonance, spintronics and spin-chemistry together. In all three areas, hyperpolarization is deployed to enhance efficiency. We will focus on molecular systems, starting with small molecules, moving to oligomers and proteins, and finally to organometallic and covalent-organic frameworks (MOFs and COFs). The research of the CRC HYP*MOL, organized into four joint work packages (JWP) will allow to: (i) bring photo-CIDNP µ-MRI (photochemically indexed dynamic nuclear polarization micro-magnetic resonance imaging) to biomedical applications (JWP1); (ii) increase the understanding of spin transport mechanisms in molecular systems and unlock the CISS effect as a new source of hyperpolarization (JWP2); (iii) establish DNP-based distance measuring for biomolecular structure determination (JWP3), and (iv) achieve hyperpolarization on demand for magnetic imaging or photocatalytic applications by MOFs and COFs (JWP4). The fields of magnetic resonance, spintronics, and spin-chemistry will profit from the concerted approach of the CRC. The close collaboration between these three fields will lead to a unified molecular spin-science. Our two research areas provide critical masses for development of hyperpolarization-based methods for structure, imaging, and sensorics (Research area A) and rationally designed molecular systems for hyperpolarization (Research area B). All projects are carried out by interdisciplinary teams consisting of two to three group leaders combining experts in synthesis, analytics, and theory. Our integrated research training group (iRTG) will train the young spin-scientists the benefits of looking beyond the horizon of single research field and making use of concepts from the three communities joined by the CRC. HYP*MOL builds on an excellent research infrastructure at both locations in Leipzig and Chemnitz and integrates leaders in the field strategically at additional partner universities. Our consortium develops up-to-date regional interdisciplinary information technology networks. We place particular emphasis on gender equality issues and on improving work-family balance.

电子和许多原子核不仅携带电荷，而且还携带称为“自旋”的磁矩。电子或磁核的瞬态自旋序的受控实现，即，分子系统中的超极化，预计将对化学和物理学的三个研究领域产生重大影响，即磁共振，自旋电子学和自旋化学，并对医学，多功能电子学或高产催化等实际应用产生影响。CRC HYP*MOL将有助于对电子和核自旋超极化的产生、其通过分子结构的传输及其控制的基本理解。为此，HYP*MOL将把磁共振、自旋电子学和自旋化学领域结合在一起。在所有三个领域，超极化部署，以提高效率。我们将专注于分子系统，从小分子开始，转移到低聚物和蛋白质，最后到有机金属和共价有机框架（MOFs和COFs）。CRC HYP*MOL的研究分为四个联合工作包（JWP），将允许：（i）将照片-CIDNP µ-MRI（ii）增加对分子系统中自旋输运机制的理解，并解开CISS效应作为超极化的新来源（JWP 2）;（iii）建立用于生物分子结构确定的基于DNP的距离测量（JWP 3），以及（iv）通过MOF和COF实现磁成像或光催化应用的超极化（JWP 4）。磁共振、自旋电子学和自旋化学领域将从CRC的协调方法中受益。这三个领域之间的密切合作将导致统一的分子自旋科学。我们的两个研究领域为开发基于超极化的结构，成像和传感方法（研究领域A）和合理设计的超极化分子系统（研究领域B）提供了临界质量。所有项目都由跨学科团队进行，该团队由两到三名组长组成，结合了综合，分析和理论方面的专家。我们的综合研究培训小组（iRTG）将培训年轻的旋转科学家了解超越单一研究领域的视野并利用CRC加入的三个社区的概念的好处。HYP*MOL建立在莱比锡和切姆尼茨两个地点的优秀研究基础设施之上，并在其他合作大学战略性地整合了该领域的领导者。我们的联盟开发最新的区域跨学科信息技术网络。我们特别重视性别平等问题和改善工作与家庭的平衡。