Novel Fluorinated Bioorganic Molecules for the 21st Century

21 世纪的新型氟化生物有机分子

• 批准号: 09044277
• 负责人: TAKEUCHI Yoshio
• 金额: $ 4.1万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044277/
• 关键词: Fluoro-amino Acid; Fluorine-containing Peptide; Isostere; Fluorination; Chiral Derivating Agent; Lipase; DAST

This international joint project between Japan-USA-Germany entitled "Novel Fluorinated Bioorganic Molecules for the 21st Century" was started in 1997 with Prof.Yoshio Takeuchi of Toyama Medical and Pharmaceutical University as the head investigator, Dr.Kenneth L.Kirk of NIH, USA, Prof. Guenter Haufe of Westfalische-Wilhelms University, Germany, Prof. Toshio Satoh of Tokushima Bunri University, Prof. Tadashi Kometani of Toyama National College of Technology, Drs.Norio Shibata and Tamiko Takahashi of Toyama Medical and Pharmaceutical University as co-investigators. Two additional co-investigators, Prof.Siegfried Lodwig of Los Alamos Laboratory (Centralia College), USA, and Dr.Masayuki Kirihara of Toyama Medical and Pharmaceutical University were invited to this project when the amount of the grant was generously increased at the end of 1997. The numbers of international and domestic trips for collaborative work funded by the project for the period (1997/1998) are summarized as follows. Travels from Japan to USA (4) ; from Japan to Germany (4) ; from USA to Germany (2) ; from USA to Japan (3) ; from Germany to Japan (1), and domestic travels in Japan (6). As part of these travels by the participants of the project, each visiting collaborator has presented his/her up-to date research results. In addition, scientific exchanges made possible by these trips have provided information dealing with on-going research, and allowed discussions of time requirements, themes, and the style of future collaborations. As a result of such interchanges, a total of 60 scientific papers were published by these investigators for 1997/1998, and a total of more than 100 presentation were made at international and domestic scientific meetings.

这个名为“21世纪新型氟化生物有机分子”的日美德国际联合项目于1997年启动，由富山医药大学的yoshio Takeuchi教授担任首席研究员，美国国立卫生研究院的kenneth L.Kirk博士，德国威斯特法利施-威廉姆斯大学的Guenter Haufe教授，德岛文理大学的佐藤敏夫教授，富山国立技术学院的kometanashi教授，富山国立技术学院的Kometani博士。富山医药大学的柴田典雄和高桥Tamiko作为共同研究人员。另外两名共同研究人员，美国洛斯阿拉莫斯实验室（森特勒利亚学院）的siegfried Lodwig教授和富山医药大学的masayuki Kirihara博士在1997年底慷慨增加资助金额时被邀请参加该项目。在此期间（1997/1998年）由该项目资助的合作工作的国际和国内旅行次数摘要如下。从日本到美国旅行(4)；从日本到德国(4)；从美国到德国(2)；从美国到日本(3)；从德国到日本(1)，以及在日本国内旅行(6)。作为项目参与者旅行的一部分，每个访问合作者都展示了他/她最新的研究成果。此外，这些旅行所带来的科学交流提供了有关正在进行的研究的信息，并允许讨论时间要求、主题和未来合作的方式。由于这种交流，这些研究人员在1997/1998年度共发表了60篇科学论文，并在国际和国内科学会议上发表了100多篇报告。

项目成果

H.Yokoyama et al.: "Asymmetric Synthesis of Chiral 2-Fluorinated 1,3-Propanediols and its Application to the Preparation of Monofluorinated Chiral Synthon" Tetrehedron Lett.39. 7741-7744 (1998)

H.Yokoyama 等人：“手性 2-氟化 1,3-丙二醇的不对称合成及其在单氟化手性合成子制备中的应用”Tetrehedron Lett.39。

Y.Takeuchi et al.: "Efficient Synthesis of A New, Highly Versatile Chiral Derivatizing Agent, α-Cyano-α-fluoro/p-tilylacetic Acid (CFTA)" Chem.Commun.1998. 365-366 (1998)

Y.Takeuchi 等人：“新型、高度通用的手性衍生剂 α-氰基-α-氟/对苯乙酸 (CFTA) 的高效合成”Chem.Commun.1998 (1998)。

H.Yokoyama et al: "Asymmetric synthesis of chiral 2-Fluorinated 1,3-Propanediols and Its Application to the Preparation of Monofbcorinated chiral synthon" Tetrahedron Lett.39. 7741-7744 (1998)

H.Yokoyama等人：“手性2-氟化1,3-丙二醇的不对称合成及其在单纤手性合成子制备中的应用”Tetrahedron Lett.39。

Y.Takeuchi et al.: "Chemistry of alpha-Fluoro-alpha-amino Acids : The First Synthesis of alpha-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)

Y.Takeuchi 等人：“α-氟-α-氨基酸的化学：含α-氟-甘氨酸二肽的首次合成”Chem.Pharm.Bull.46。

Y.Takeuchi et al.: "Chemistry of α-Fluoro-α-amino Acids : The First Synthesis of α-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)

Y.Takeuchi 等人：“α-氟-α-氨基酸的化学：含α-氟-甘氨酸的二肽的首次合成”Chem.Pharm.Bull.46 (1998)。