Novel Fluorinated Bioorganic Molecules for the 21st Century
Novel Fluorinated Bioorganic Molecules for the 21st Century
批准号:
09044277
负责人:
TAKEUCHI Yoshio
金额:
$4.1万
依托单位国家:
日本
项目类别:
Grant-in-Aid for international Scientific Research
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
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英文摘要
This international joint project between Japan-USA-Germany entitled "Novel Fluorinated Bioorganic Molecules for the 21st Century" was started in 1997 with Prof.Yoshio Takeuchi of Toyama Medical and Pharmaceutical University as the head investigator, Dr.Kenneth L.Kirk of NIH, USA, Prof. Guenter Haufe of Westfalische-Wilhelms University, Germany, Prof. Toshio Satoh of Tokushima Bunri University, Prof. Tadashi Kometani of Toyama National College of Technology, Drs.Norio Shibata and Tamiko Takahashi of Toyama Medical and Pharmaceutical University as co-investigators. Two additional co-investigators, Prof.Siegfried Lodwig of Los Alamos Laboratory (Centralia College), USA, and Dr.Masayuki Kirihara of Toyama Medical and Pharmaceutical University were invited to this project when the amount of the grant was generously increased at the end of 1997. The numbers of international and domestic trips for collaborative work funded by the project for the period (1997/1998) are summarized as follows. Travels from Japan to USA (4) ; from Japan to Germany (4) ; from USA to Germany (2) ; from USA to Japan (3) ; from Germany to Japan (1), and domestic travels in Japan (6). As part of these travels by the participants of the project, each visiting collaborator has presented his/her up-to date research results. In addition, scientific exchanges made possible by these trips have provided information dealing with on-going research, and allowed discussions of time requirements, themes, and the style of future collaborations. As a result of such interchanges, a total of 60 scientific papers were published by these investigators for 1997/1998, and a total of more than 100 presentation were made at international and domestic scientific meetings.
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H.Yokoyama et al.: "Asymmetric Synthesis of Chiral 2-Fluorinated 1,3-Propanediols and its Application to the Preparation of Monofluorinated Chiral Synthon" Tetrehedron Lett.39. 7741-7744 (1998)
H.Yokoyama 等人:“手性 2-氟化 1,3-丙二醇的不对称合成及其在单氟化手性合成子制备中的应用”Tetrehedron Lett.39。
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作者:
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通讯作者:
Y.Takeuchi et al.: "Efficient Synthesis of A New, Highly Versatile Chiral Derivatizing Agent, α-Cyano-α-fluoro/p-tilylacetic Acid (CFTA)" Chem.Commun.1998. 365-366 (1998)
Y.Takeuchi 等人:“新型、高度通用的手性衍生剂 α-氰基-α-氟/对苯乙酸 (CFTA) 的高效合成”Chem.Commun.1998 (1998)。
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发表时间:
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作者:
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通讯作者:
H.Yokoyama et al: "Asymmetric synthesis of chiral 2-Fluorinated 1,3-Propanediols and Its Application to the Preparation of Monofbcorinated chiral synthon" Tetrahedron Lett.39. 7741-7744 (1998)
H.Yokoyama等人:“手性2-氟化1,3-丙二醇的不对称合成及其在单纤手性合成子制备中的应用”Tetrahedron Lett.39。
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Y.Takeuchi et al.: "Chemistry of alpha-Fluoro-alpha-amino Acids : The First Synthesis of alpha-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)
Y.Takeuchi 等人:“α-氟-α-氨基酸的化学:含α-氟-甘氨酸二肽的首次合成”Chem.Pharm.Bull.46。
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发表时间:
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影响因子:
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作者:
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通讯作者:
Y.Takeuchi et al.: "Chemistry of α-Fluoro-α-amino Acids : The First Synthesis of α-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)
Y.Takeuchi 等人:“α-氟-α-氨基酸的化学:含α-氟-甘氨酸的二肽的首次合成”Chem.Pharm.Bull.46 (1998)。
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共 21 条
Design & Synthesis of Novel Enantioselctive Fluorinationg Agents
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批准号:10557206
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.2万
-
财政年份:1998
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负责人:TAKEUCHI Yoshio
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依托单位:
Efficient preparation of a highly versatile chiral derivatizing agent, CFTA, for determination of absolute configurations.
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批准号:10470465
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.71万
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财政年份:1998
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负责人:TAKEUCHI Yoshio
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依托单位:
Development of Electrophilic and Enantioselective Fluorinating Agents based on Fine Chemisty Design
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批准号:07807193
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1995
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负责人:TAKEUCHI Yoshio
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依托单位:
Synthesis and Utilization of Fluorine-containing Chiral Building Blocks for Development of the New Type of Drugs
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批准号:07557304
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.47万
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财政年份:1995
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负责人:TAKEUCHI Yoshio
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依托单位:
Development of the Reagents for Electrophilic Fluorination Directing for New Type of Medicinals
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批准号:05807199
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1993
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负责人:TAKEUCHI Yoshio
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依托单位:
Development of A New Reagent for Ee Determination with High Resolution Based on the Fine Chemistry Designing
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批准号:02670949
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1990
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负责人:TAKEUCHI Yoshio
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依托单位:
Synthesis of Monofluoro Building Blocks Designed from Fine Chemistry Viewpoint and Development of Fluorine-containing Medicinals
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批准号:02557086
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$3.46万
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财政年份:1990
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负责人:TAKEUCHI Yoshio
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依托单位:
The study of complex mineral and inorganic structures by means of computer graphics
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批准号:62580043
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1987
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负责人:TAKEUCHI Yoshio
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依托单位:
Synthesis and Application of Versatile Monofluoro Building Blocks by Manipulation of the Multifunctional Carbon Compounds.
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批准号:62570934
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1987
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负责人:TAKEUCHI Yoshio
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依托单位: