Role of Nitric Oxide (NO) and K^+ channels in adrenal catecholamine secretion in anesthetized dogs

一氧化氮 (NO) 和 K^ 通道在麻醉犬肾上腺儿茶酚胺分泌中的作用

• 批准号: 09470510
• 负责人: SATOH Susumu
• 金额: $ 1.86万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470510/
• 关键词: Adrenal Catechplamine Secretion; Nitric oxide (NO); L-NAME; NOC7; K^+ channels; charybdotoxin; MCD peptide; scyllatoxin; NOC7; K^+チャンネル; 副腎; カテコールアミン; NO; Kチャネル; BKチャネル; チャリブドトキシン; アセチルコリン

We investigated the functional role of Nitric Oxide (NO) and K^+ channels in adrenal catecholamine secretion in nesthetized dogs.(1) Small conductance Ca^<2+>-activated K^+ (SKCa) channels located in adrenal medullary chromaffin cells may play an inhibitory role in the regulation of adrenal catecholamine secretion mediated by extrasynaptic nicotinic and muscarinic receptors.(2) High conductance Ca^<2+>-activated K^+ (BKCa) channels may have no role in catecholamine secretion.(3) Voltage-dependent K^+ channnels (KA type) may play an inhibitory role in the regulation of the neuronally-evoked secretion of adrenal catecholamines.(4) Nitric oxide may play an inhibitory role in the regulation of adrenal catecholamine secretion in response to exogenous acetylcholine.(5) Nitric oxide may inhibit the neuronally-evoked secretion of adrenal catecholamines through activation of BKCa channels.

我们研究了一氧化氮（NO）和K^+通道在麻醉犬肾上腺分泌儿茶酚胺中的功能作用。(1)位于肾上腺髓质嗜铬细胞的小电导Ca^2+激活K^+通道（SKCa）可能在突触外烟碱和毒蕈碱受体介导的肾上腺儿茶酚胺分泌调节中起抑制作用。(2)高电导Ca^<2+>激活的K^+（BKCa）通道可能在儿茶酚胺分泌中没有作用。(3)电压依赖性K^+通道（KA型）可能在神经元诱发的肾上腺儿茶酚胺分泌的调节中起抑制作用。(4)一氧化氮可能在外源性乙酰胆碱刺激肾上腺分泌儿茶酚胺的调节中起抑制作用。(5)一氧化氮可能通过激活BKCa通道抑制肾上腺儿茶酚胺的神经元诱发分泌。

项目成果

T.Nagayama, K.Masada, M.Yoshida, M.Suzuki-Kusaba, H.Hisa, T.Kimura and S.Satoh: "Role of K^+ channels in adrenal catecholamine secretion in anesthetized dogs" American Journal of Physiology. 274. R1125-R1130 (1998)

T.Nagayama、K.Masada、M.Yoshida、M.Suzuki-Kusaba、H.Hisa、T.Kimura 和 S.Satoh：“K^ 通道在麻醉狗肾上腺儿茶酚胺分泌中的作用”美国生理学杂志。

T.Nagayama: "Apamin-sensitive SKCa channels modulate adrenal catecholamine release in anesthetized dogs" European Journal of Pharmacology. 327. 135-141 (1997)

T.Nagayama：“Apamin 敏感 SKCa 通道调节麻醉犬肾上腺儿茶酚胺的释放”《欧洲药理学杂志》。

T.Nagayama, M.Yoshida, M.Suzuki-Kusaba, H.Hisa, T.Kimura and S.Satoh: "The role BKCa channels in the nitric oxide-mediated regulation of adrenal catecholamine secretion" European Journal of Pharmacology. 353. 169-176 (1998)

T.Nagayama、M.Yoshida、M.Suzuki-Kusaba、H.Hisa、T.Kimura 和 S.Satoh：“BKCa 通道在一氧化氮介导的肾上腺儿茶酚胺分泌调节中的作用”《欧洲药理学杂志》。

T.Nagayama: "Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs" American Journal of Physiology. 275. R1075-R1081 (1998)

T.Nagayama：“一氧化氮在麻醉狗肾上腺儿茶酚胺分泌中的作用”美国生理学杂志。

T.Nagayama, A.Hosokawa, M.Yoshida, M.Suzuki-Kusaba, H.Hisa, T.Kimura and S.Satoh: "Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs" American Journal of Physiology. 275. R1075-R1081 (1998)

T.Nagayama、A.Hosokawa、M.Yoshida、M.Suzuki-Kusaba、H.Hisa、T.Kimura 和 S.Satoh：“一氧化氮在麻醉狗肾上腺儿茶酚胺分泌中的作用”美国生理学杂志。