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Role of Nitric Oxide (NO) and K^+ channels in adrenal catecholamine secretion in anesthetized dogs

Role of Nitric Oxide (NO) and K^+ channels in adrenal catecholamine secretion in anesthetized dogs
一氧化氮 (NO) 和 K^ 通道在麻醉犬肾上腺儿茶酚胺分泌中的作用
批准号:
09470510
负责人:
SATOH Susumu
金额:
$1.86万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998

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中文摘要
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英文摘要
We investigated the functional role of Nitric Oxide (NO) and K^+ channels in adrenal catecholamine secretion in nesthetized dogs.(1) Small conductance Ca^<2+>-activated K^+ (SKCa) channels located in adrenal medullary chromaffin cells may play an inhibitory role in the regulation of adrenal catecholamine secretion mediated by extrasynaptic nicotinic and muscarinic receptors.(2) High conductance Ca^<2+>-activated K^+ (BKCa) channels may have no role in catecholamine secretion.(3) Voltage-dependent K^+ channnels (KA type) may play an inhibitory role in the regulation of the neuronally-evoked secretion of adrenal catecholamines.(4) Nitric oxide may play an inhibitory role in the regulation of adrenal catecholamine secretion in response to exogenous acetylcholine.(5) Nitric oxide may inhibit the neuronally-evoked secretion of adrenal catecholamines through activation of BKCa channels.
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T.Nagayama, K.Masada, M.Yoshida, M.Suzuki-Kusaba, H.Hisa, T.Kimura and S.Satoh: "Role of K^+ channels in adrenal catecholamine secretion in anesthetized dogs" American Journal of Physiology. 274. R1125-R1130 (1998)
T.Nagayama、K.Masada、M.Yoshida、M.Suzuki-Kusaba、H.Hisa、T.Kimura 和 S.Satoh:“K^ 通道在麻醉狗肾上腺儿茶酚胺分泌中的作用”美国生理学杂志。
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T.Nagayama: "Apamin-sensitive SKCa channels modulate adrenal catecholamine release in anesthetized dogs" European Journal of Pharmacology. 327. 135-141 (1997)
T.Nagayama:“Apamin 敏感 SKCa 通道调节麻醉犬肾上腺儿茶酚胺的释放”《欧洲药理学杂志》。
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通讯作者:
T.Nagayama, M.Yoshida, M.Suzuki-Kusaba, H.Hisa, T.Kimura and S.Satoh: "The role BKCa channels in the nitric oxide-mediated regulation of adrenal catecholamine secretion" European Journal of Pharmacology. 353. 169-176 (1998)
T.Nagayama、M.Yoshida、M.Suzuki-Kusaba、H.Hisa、T.Kimura 和 S.Satoh:“BKCa 通道在一氧化氮介导的肾上腺儿茶酚胺分泌调节中的作用”《欧洲药理学杂志》。
DOI: --
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作者: []
通讯作者:
T.Nagayama: "Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs" American Journal of Physiology. 275. R1075-R1081 (1998)
T.Nagayama:“一氧化氮在麻醉狗肾上腺儿茶酚胺分泌中的作用”美国生理学杂志。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
13
    Development of the dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase as the antihypertensive drugs
    • 批准号:
      09557209
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
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    • 财政年份:
      1997
    • 负责人:
      SATOH Susumu
    • 依托单位:
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
      $1.15万
    • 财政年份:
      1994
    • 负责人:
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    • 依托单位:
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    • 批准号:
      61570091
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.28万
    • 财政年份:
      1986
    • 负责人:
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    • 依托单位:
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