How does embryonic physiology shape the divergence of brain development?

胚胎生理学如何影响大脑发育的差异？

• 批准号: DP240102458
• 负责人: Dr Laura Fenlon
• 金额: $ 46.96万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102458
• 关键词: How; does; embryonic; physiology; shape

Unlike placental mammals (humans, mice, dogs etc) marsupials give birth to very immature young that finalise development in the pouch. Despite this remarkable distinction in the major mammalian lineages, very little is known about how differing reproductive environments impact development and evolution. This project aims to explore how developing inside or outside a uterus impacts brain development in placental vs marsupial mammals. Expected outcomes include expanding theories of how different body systems are connected in development and evolution, understanding what aspects of marsupial development might be especially sensitive to variations in environment brought about by climate change and enhancing Australia’s research capabilities.

与胎盘哺乳动物（人类、老鼠、狗等）不同，有袋动物产下的幼崽非常不成熟，在育儿袋中完成发育。尽管在主要的哺乳动物谱系中存在这种显著的差异，但人们对不同的生殖环境如何影响发育和进化知之甚少。本项目旨在探讨子宫内外发育如何影响胎盘类和有袋类哺乳动物的大脑发育。预期的结果包括扩展关于不同身体系统如何在发育和进化中相互联系的理论，了解有袋动物的哪些方面对气候变化带来的环境变化特别敏感，以及提高澳大利亚的研究能力。