Pathological and Epidemiological Study on the Relationship between Electromagnetic Field Exposure and Lung Cancer.

电磁场暴露与肺癌关系的病理学和流行病学研究。

• 批准号: 09670381
• 负责人: SOKEJIMA Shigeru
• 金额: $ 1.98万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670381/
• 关键词: Lung Cancer; Tissue Sample; Remanent Magnetization; Superconducting Quantum Interference Device (SQUID); 肺癌; 肺組織標本; 磁化強度

Remanent magnetization of lung tissues of 14 cases of lung cancers and 11 cases of other patients was studied using Superconducting Quantum Interference Device (SQUID). Natural remanent magnetization (NRM) of the specimen from lung cancer tissue (8.00 ± 13.11 × 10ィイD1-7ィエD1 emu) was two times stronger than that of the normal lung tissue (3.35 ± 3.35 × 10ィイD1-7ィエD1 emu), and was significantly stronger than that of the controls and the noise level of superconducting magnetometer. When comparing the NRM of 5 kinds of tissues from other patients, lung tissues had the highest value, followed by heart, spleen and kidney. Liver tissue had the lowest value. NRM of all the 5 tissues were stronger than that of controls, indicating that the normal tissues contained the magnetic materials. The biological magnetite is the possible magnetic material in these tissues. Two cases of specimens with highly magnetized lung cancer tissue are especially studied on their magnetic properties. Alternating fiel … More d demagnetization experiment shows that the magnetization of them is a stable one vector component which indicates that the lung tissue may have been magnetized after the accumulation of the magnetic materials. Wohlfarth ratio of them is determined as the value less than 0.5, suggesting that the magnetic materials exist in the lung tissue as the cluster distribution.The meta-analysis was Used to summarize the results of epidemiological studies on the relationship between occupational exposure to an electromagnetic field (EMF) and the risk of adult leukemia. The combined relative risk of all leukemia (RR=1.11), as well as acute lymphocytic leukemia (RR=1.38), acute myeloid leukemia (RR=1.07) and chronic lymphocytic leukemia (RR=1.14) increased but not significantly. So far, it is difficult to make a consistent conclusion about the relationship of the occupational exposure to EMF and adult leukemia. Further carefully designed case-control and cohort studies using the more valid means of exposure assessment are required. Less

用超导量子干涉仪（SQUID）研究了14例肺癌和11例非肺癌患者肺组织的剩磁。肺癌组织的自然回复磁化强度（8.00 ± 13.11 × 10 ~（-1）~（-7）μ D_1emu）是正常肺组织（3.35 ± 3.35）× 10 ~（-1）~（-7）μ D_1emu）的2倍，明显高于正常对照组和超导磁强计的噪声水平。比较其他患者5种组织的NRM，肺组织的NRM值最高，其次是心、脾和肾。肝组织最低。5种组织的NRM均强于对照组，表明正常组织中含有磁性物质。生物磁铁矿是这些组织中可能的磁性物质。本文着重研究了两例强磁化肺癌组织的磁特性。交变磁场 ...更多信息 三维退磁实验表明，它们的磁化强度是一个稳定的单矢量分量，说明肺组织可能是在磁性物质积累后被磁化的。采用Meta分析方法，对职业性电磁场暴露与成人白血病发病风险的流行病学研究结果进行了总结。所有白血病（RR=1.11）以及急性淋巴细胞白血病（RR=1.38）、急性髓细胞白血病（RR=1.07）和慢性淋巴细胞白血病（RR=1.14）的联合相对危险度增加，但不显著。职业性电磁场暴露与成人白血病的关系目前尚无一致的结论。需要进一步仔细设计病例对照和队列研究，使用更有效的暴露评估方法。少

项目成果

王紅兵、そうけ島茂、関根道和、酒井英男、鏡森定信: "超伝導残留磁気測定装置(SQUID)によるヒト正常組織及び肺ガンと非肺ガン症例の組織の残留磁化の研究"第70回日本衛生学会総会. 55・1(印刷中). (2000)

王红北、Shigeru Souke Shima、Michikazu Sekine、Hideo Sakai、Sadanobu Kagamori：“使用超导剩磁测量装置（SQUID）对人体正常组织和肺癌及非肺癌组织中的剩磁进行研究”年刊第70期日本卫生学会总会大会 55・1（印刷中）。

王紅兵、〓島茂、関根道和、鏡森定信: "超伝導残留磁気測定装置(SQUID)による人間正常組織の残留磁化の研究" 日本衛生学雑誌. 54・1. 324 (1999)

王宏北、岛茂、关根道和、镜守贞信：“使用超导剩磁测量装置（SQUID）研究正常人体组织的剩磁”日本卫生杂志 54・1（1999）。

王紅兵、そうけ島茂、関根道和、劉仲玉、鏡森定信: "電磁場の職業曝露と成人白血病に関する疫学のメタ分析"日本公衆衛生雑誌. 45・10. 113 (1998)

Hongbei Wang、Shigeru Soke Shima、Michiwa Sekine、Zhongyu Liu、Sadanobu Kagamori：“职业暴露于电磁场和成人白血病流行病学的荟萃分析”日本公共卫生杂志 45, 10. 113 (1998)。

王紅兵、〓島茂、鏡森定信: "電磁場に関する発がん性の疫学研究" 癌の臨床. 44・12. 1459-1463 (1988)

王红北、岛繁、镜守贞信：“与电磁场相关的致癌性的流行病学研究”《临床癌症研究》44・12 1459-1463（1988）。

王紅兵、そうけ島茂、鏡森定信: "電磁場に関する発ガン性の疫学研究"癌の臨床. 44・12. 1459-1463 (1998)

王红北、岛茂壮介、镜森贞信：“与电磁场相关的致癌性的流行病学研究”《临床癌症研究》44・12（1998）。