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Detection of HGV mutation and pathological relation

HGV突变检测及病理关系

基本信息

批准号：
09670480
负责人：
HAYASHI Jun
金额：
$ 1.47万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670480/
关键词：
hepatitis G virus hepatitis C virus STD interferon coinfection epidemiology G型肝炎ウイルス C型肝炎

项目摘要

To clarify the hepatitis G virus (HGV) transmission routes and its affect on liver function, we surveyed for HGV infection among the general population, hemodialysis patients, female prostitutes and patients with chronic liver disease caused by hepatitis C virus (HCV). We developed a primer for the detection of hepatitis G virus (HGV). We detected HGV RNA by PCR and measured antibody to envelope-2 of HGV (anti-E2) by ELISA.The prevalence of HGV RNA and/or anti-E2 was 10.7% in 298 persons of the general population, 10.7% in 225 hemodialysis patients, and 24.8% in female prostitutes. The chronic viremia rate of HGV (21.7%) was significantly lower than that of HCV (83.2%) (p<0.001) and significantly higher than that of hepatitis B virus (HBV) (5.3%) (p<0.001). Among the hemodialysis patients, the prevalence of EGV RNA was correlated with the number of blood transfusions and the duration of dialysis. Among female prostitutes, the prevalences of HGV and/or anti-E2 was correlated with number of years engaged in prostitution. The prevalence of HGV RNA in 274 patients with chronic liver disease C was 8.9%, with no relation between HGV presence or absence and the severity of liver disease. Moreover, interferon eliminates HGV RNA from the serum.In conclusion, HGV is transmitted by blood transfusion, medical intervention and sexual intercourse as are HCV and HBV.HGV infection has no apparent affect HCV infection.

为明确丙型肝炎病毒（HGV）的传播途径及其对肝功能的影响，我们对普通人群、血液透析患者、妓女和丙型肝炎病毒（HCV）慢性肝病患者进行了丙型肝炎病毒（HCV）感染调查。研制了一种检测G型肝炎病毒（HGV）的引物。采用PCR检测HGV RNA， ELISA检测HGV包膜-2抗体（抗e2）。298名普通人群中HGV RNA和/或抗e2的患病率为10.7%，225名血液透析患者中为10.7%，女性妓女中为24.8%。HGV的慢性病毒血症率（21.7%）显著低于HCV (83.2%) (p<0.001)，显著高于乙型肝炎病毒（HBV）（5.3%）（p<0.001）。在血液透析患者中，EGV RNA的流行与输血次数和透析时间相关。在妓女中，HGV和/或抗e2的患病率与从事卖淫的年数相关。274例慢性丙型肝病患者中HGV RNA的患病率为8.9%，HGV存在与否与肝病严重程度无关。此外，干扰素可以消除血清中的HGV RNA。总之，HGV通过输血、医疗干预和性交传播，HCV和HBV也是如此。HGV感染对HCV感染无明显影响。