Contraction-excitation feedback in heart failure and cardiac hypertrophy
心力衰竭和心脏肥大中的收缩-兴奋反馈
基本信息
- 批准号:09670691
- 负责人:
- 金额:$ 1.92万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The mechanical stress has been reported to affect the process of electrical excitation in the heart. This phenomenon is called to be "contraction-excitation feedback". Although it has been considered that the stretch activated ion channel is involved in its mechanisms, the precise mechanism is unclear.We measured QT-interval as an indicator of electrical excitation in various conditions such as pressure-overload to the left ventricic, volume-overload to the left ventricle, valsalva stimulation, dysopyramide application. Furthermore, we also studied myocardial endothelin-1 and contraction- excitation feedback.Cardiac myocytes as well as vascular endothelium produce endothelin (ET)-1. In the heart, ET-1 induces myocardial hypertrophy and causes cellular injury of cardiac myocytes. In this study, we investigated roles of ET-1 in heart diseases such as chronic heart failure (CHF) and cardiac hypertrophy. We used coronary artery-ligated rat model as a CHF model animal (CHF rats). It was rev … More ealed that production of ET-1 (both peptide and mRNA levels) is increased in the ailing heart of the CHF rats. We also obtained the data that the upregulated myocardial ET-1 system may play an aggravating role in the progression of CHF, because long-term (12 weeks) treatment with the ET receptor antagonist BQ-123 greatly improved survival rate of CHF rats. Twelve weeks after BQ-123 application, survival rate of the GHF rats treated with BQ-123 (CHF-BQ rats) was markedly higher than that of the CHF rats treated with saline alone (CHF-saline rats) (85% vs 43%, P< 0.01).Hemodynamic parameters of surviving rats were ameliorated by chronic BQ-123 treatment. BQ-123 treatment effectively prevented unfavorable ventricular remodeling of the CHF rats. In the hypertrophied left ventricle of the aorta-banded rats, the expression of ET-1 mRNA was significantly increased. Treatment with BQ-123 for 7 days significantly reduced cardiac hypertrophy of the aorta- banded rats. In these rats treated with BQ-123, the expression of mRNA of myocardial ion channels was altered.These findings suggest that contraction-excitation feedback mechanism is involved in arrhythmias in heart failure and cardiac hypertrophy. Less
据报道,机械应力会影响心脏的电兴奋过程。这种现象被称为“收缩-兴奋反馈”。虽然一直认为拉伸激活离子通道参与了其机制,但其确切机制尚不清楚。我们测量了qt间期作为各种条件下电兴奋的指标,如左心室压力过载、左心室容量过载、valsalva刺激、心肌功能失调。此外,我们还研究了心肌内皮素-1和收缩-兴奋反馈。心肌细胞和血管内皮产生内皮素(ET)-1。在心脏中,ET-1诱导心肌肥大,引起心肌细胞损伤。在这项研究中,我们探讨了ET-1在慢性心力衰竭(CHF)和心脏肥厚等心脏疾病中的作用。我们采用冠状动脉结扎大鼠模型作为CHF模型动物(CHF大鼠)。结果表明,CHF大鼠患病心脏中ET-1的产生(肽和mRNA水平)均增加。我们还获得的数据表明,心肌ET-1系统的上调可能在CHF的进展中起加重作用,因为长期(12周)使用ET受体拮抗剂BQ-123治疗可以大大提高CHF大鼠的存活率。应用BQ-123 12周后,BQ-123处理的GHF大鼠(CHF- bq大鼠)的存活率显著高于单独用生理盐水处理的CHF大鼠(CHF-生理盐水大鼠)(85% vs 43%, P< 0.01)。慢性BQ-123治疗可改善存活大鼠血流动力学参数。BQ-123治疗可有效预防CHF大鼠的不利心室重构。主动脉束带大鼠肥大左心室ET-1 mRNA表达明显升高。BQ-123治疗7天可显著减轻主动脉束带大鼠心肌肥厚。BQ-123可改变心肌离子通道mRNA的表达。这些结果提示,心衰和心脏肥厚性心律失常可能与收缩-兴奋反馈机制有关。少
项目成果
期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Maeda S,Miyauchi T,Sakai S,Kobayashi T,Iemitsu M,Goto K,Sugishita Y,Matsuda M.: "Prolonged exercise causes an increase in endothelin-1 production in the heart in rats." American Journal of Physiology. 275. H2105-H2112 (1998)
Maeda S、Miyauchi T、Sakai S、Kobayashi T、Iemitsu M、Goto K、Sugishita Y、Matsuda M.:“长时间运动会导致大鼠心脏中内皮素 1 的产生增加。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
山口巌,et.al.: "時空間心電情報の定量化とその診断応用" Japanese Circulation Journal. 61(suppII). 902-912 (1998)
Iwao Yamaguchi 等人:“时空心电图信息的量化及其诊断应用”,日本循环杂志 61(增刊 II)(1998 年)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tsutomu Kobayashi, et.al.: "Down-regulation of ET_B receptor,but not ET_A receptor,in congestive lung secondary to heart failure" Life Sciences. vol.62 No.2. 185-193 (1998)
Tsutomu Kobayashi 等人:“在继发于心力衰竭的充血性肺中,ET_B 受体下调,但不是 ET_A 受体”生命科学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Maeda S,Miyauchi T,Kobayashi T,Goto K,Matsuda M.: "Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs." Journal of Appllied Physiology. 85. 425-431 (1998)
Maeda S、Miyauchi T、Kobayashi T、Goto K、Matsuda M.:“运动会导致内脏器官中内皮素 1 mRNA 表达的组织特异性增强。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Sakai S,et al.: "Oistribution of endothelin-2 in the lung of rats with pulmonary hypartension of different etiology" International Journal of Angiology. vol.7. 160-164 (1998)
Sakai S 等人:“不同病因肺动脉高压大鼠肺内皮素 2 的分布”,《国际血管学杂志》。
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- 影响因子:0
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YAMAGUCHI Iwao其他文献
YAMAGUCHI Iwao的其他文献
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{{ truncateString('YAMAGUCHI Iwao', 18)}}的其他基金
肥大心における機械的収縮、電気的興奮のフィードバック機構の不整脈発生に対する関与-Stretch activated channel の関与と自律神経が与える影響について-
肥厚心脏心律失常中机械收缩和电兴奋反馈机制的参与 - 牵张激活通道的参与和自主神经的影响 -
- 批准号:
07670751 - 财政年份:1995
- 资助金额:
$ 1.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
HISTORY OF THE FOUNDATION AND THE RULE OF KIPCHAK KHANATE IN RUSSIA.
基金会的历史和俄罗斯钦察汗国的统治。
- 批准号:
06610466 - 财政年份:1994
- 资助金额:
$ 1.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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