A STUDY OF THE RELATION BETWEEN POLYMORPHISM OF STEROID RECEPTOR AND CLINICAL COURSE IN IgA NEPHROPATHY IN CHILDREN

[1]的文件。目的：探讨雌激素受体（ER）和血管紧张素转换酶（ACE）基因多态性对伊加肾病临床和病理预后的影响。[2]的文件。材料与方法：本研究纳入了74名接受包括泼尼松龙在内的方案治疗2年且治疗后可以进行连续肾活检的伊加肾病儿童。提取外周血单个核细胞DNA，PCR扩增ER和ACE基因，RFLP分析其多态性。分析这些基因多态性与伊加肾病患儿临床指标的关系。[3]的文件。结果：（1）ER基因多态性中，PP型9例（18.3%），Pp型35例（71.5%），pp型5例（10.2%）。25例患者未被研究或其基因无法扩增。(2)ACE基因多态性中，II型14例（25.9%），ID型28例（51.9%），DD型12例（22.2%）。20例患者未被研究或其基因无法扩增。(3)PP患儿的慢性指数在治疗后显著降低，但在Pp和pp患儿中无变化。(4)治疗前，ID和DD儿童的活动指数显著高于II儿童。虽然没有统计学意义，但治疗后的慢性指数在ID和DD儿童中较高。无II型患者治疗后尿常规恶化。另一方面，它在一些ID和DD患者中恶化。

[1]. Purpose :In this study, we investigated whether the polymorphism of estrogen receptor (ER) and ACE gene had any effect on the clinical or histological prognosis of IgA nephropathy.[2]. Material and Method :74 children with IgA nephropathy, who were treated with the protocol including prednisolone for 2 years, and serial renal biopsy could be performed after treatment, were included in this study. DNA was extracted from peripheral mononuclear cells, genes of ER and ACE were amplified by PCR and polymorphism of them were examined with RFLP. The relation of clinical parameters of children with IgA nephropathy and polymorphisms of these genes were analyzed.[3]. Results :(1) In the polymorphism of ER gene, 9 were PP (18.3%), 35 were Pp (71.5%) and 5 were pp (10.2%). 25 patients cold not be studied or their genes could not be amplified.(2) In the polymorphism of ACE gene, 14 were II (25.9%), 28 were ID (51.9%) and 12 were DD (22.2%). 20 patients cold not be studied or their genes could not be amplified.(3) Chronicity index was significantly reduced by treatment in the children with PP, but not changed in the children with Pp and pp.(4) Before treatment, activity index was significantly high in the children with ID and DD, compared with the children with II. Although statistically not significant, chronicity index after treatment was higher in the children with ID and DD. There was no patient with II, whose urinalysis became worse after treatment. On the other hand, it worsened in some patients with ID and DD.