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Investigations for inhibition of arterial restenosis after metallic stent placement.

金属支架置入后抑制动脉再狭窄的研究。

基本信息

批准号：
09670922
负责人：
SAKAI Toyohiko
金额：
$ 1.98万
依托单位：
Fukui Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

1) Effects of tranirast on inhibition of arterial restenosisTen rabbits were used for this experiment. Metallic stents were placed in the abdominal aorta in all rabbits. Four weeks after stent placement, all of them were sacrificed and the aortas were taken, and aortic specimen were made and microscopic obserbation was performed. For one week before and four weeks after the stent placemet, tranilast was orally treated for five of ten rabbits, and not for the other. Microscopically, all the specimen revealed intimal hyperplasia. The area of hyperplasia significantly decreased in the tranilast group than it in control.2) Chitosan coating on metallic stentChitosan(1g) was solved in acetic acid(1N, 100ml). The metallic stent was placed into the solution and taken, and it was placed into the NaOH(1N, 100ml). Although some chitosan particles were attached on the surface of metallic stent, the coating seemed uneven and imcomplete. Further investigation would be necessary.3) Effects of anticancer drugs on the vascular endotherial function.Farmorbicin(EPIR), mitomycine(MMC), and fluorouracil(5-FU) were examined for this experiment. The rat thoracic aorta was removed and placed in the Krebs solution. The helical strips were made and the relaxation response to acetylcholine(Ach) and sodium nitroprusside (SNP) were evaluated. EPIR affected the relaxation response to Ach but did not it to SNP. MMC and 5-FU did not affect the relaxation response to Ach and SNP. These results reveal EPIR impairs endotherial function.

1)曲尼司特对动脉再狭窄的抑制作用本实验使用10只兔子。所有兔子的腹主动脉均放置金属支架。支架置入4周后，全部处死并取主动脉，制作主动脉标本并进行镜下观察。在支架放置前一周和放置后四个星期，十只兔子中的五只口服曲尼司特，另一只则不口服。显微镜下，所有标本均显示内膜增生。曲尼司特组增生面积较对照组明显减少。2)金属支架上壳聚糖涂层将壳聚糖(1g)溶于乙酸(1N,100ml)。将金属支架放入溶液中取出，放入NaOH(1N，100ml)中。虽然金属支架表面附着有一些壳聚糖颗粒，但涂层显得不均匀且不完整。 3)抗癌药物对血管内皮功能的影响。本实验考察了法莫比星(EPIR)、丝裂霉素(MMC)、氟尿嘧啶(5-FU)。取出大鼠胸主动脉并置于克雷布斯溶液中。制作螺旋条并评估对乙酰胆碱（Ach）和硝普钠（SNP）的松弛反应。 EPIR 影响对 Ach 的弛豫反应，但对 SNP 没有影响。 MMC和5-FU不影响对Ach和SNP的松弛反应。这些结果表明 EPIR 损害内皮功能。