Growth factor of hair cell regeneration in auditory epithelium and cochlear nucleus

胚胎发生和再生的生长因子和粘附分子，因为两者在听上皮中相似。免疫组化显示，在妊娠期和未成熟期，听神经节和基底膜均有神经突生长因子（NOF）的表达。新的粘附分子gicerin在未成熟期的听上皮和听神经节以及声损伤后再生上皮细胞增殖活跃的区域表达。Gicerin可能与听上皮细胞的增殖有关，并与NOF一起参与听神经节细胞突起的延伸。妊娠期听上皮和听神经节的神经纤维中存在高度聚唾液酸化的神经粘附分子（NCAM-H）。出生后在听神经节也观察到。提示NCAM-H在内耳发育过程中特异性地调节传入神经纤维的生长和与毛细胞的突触发生，并可能与神经元的可塑性有关。

Growth factors and adhesion molecules of embryogenesis and regeneration, because both are similar in auditory epithelium. By immunohistochemistry neurite growth factor (NOF) was expressed in acoustic ganglion and basal membrane at gestational and immmature stages. New adhesion molecule, gicerin, was expressed in auditory epithelium and acoustic ganglion at immature stage, and in the area of active cell proliferation of regenerative epithelium after acoustic trauma. Gicerin may be associated with cell proliferation in the auditory epithelium, and play a role in neurite extension of the acoustic ganglion cells in conjunction with NOF.Highly polysialylated neural adhesion molecule (NCAM-H) was observed in nerve fibers of auditory epithelium and acoustic ganglion at gestational stage. It was also observed at acoustic ganglion after birth. It is suggested that NCAM-H specifically regulates the afferent nerve fibers' growthand synaptogenesis with hair cells during inner ear development and may be associated with neuronal plasticity.