权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Chemical Study on Industrial Products for Medicinal Resources

药用资源工业品的化学研究

基本信息

批准号：
09672174
负责人：
NIWA Masatake
金额：
$ 2.3万
依托单位：
Meijo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672174/
关键词：
Vitis vinifera Kyohou Grape Oligostilbene Antiattachment Activity NO Biogenetic Reaction Biological Activity vitisin B vitisin C ampelopsin viniferifuran vitisifuran 絶対配置スチルベンテトラマ-hopeaphenol isohopeaphenol vitisin

项目摘要

The cork of Vitis vinifera 'Kyohou' was given from the cultivator as waste products. In the course of seeking for new medicinal resources, the cork was forcused on.1. The methanol extract of the cork gave 11 novel stilbene tetramers, a novel stilbene trimer, and a novel stilbene dimer as well as many known oligostilbenes.2. The biogenetic reactions of (+)-ε-viniferin, a known stilbene dimer and a major constituent, to minor biologically active oligostilbenes were studied. Acid-catalyzed reactions of (+)-ε-viniferin gave three kinds of stilbene dimer having carbon skeletons different from (+)-ε-viniferin. A reaction of (+)-ε-viniferin with horseradish peroxidase and hydrogen peroxide gave(-)-vitisin B and (+)-vitisin C, stilebene tetramers.3. (+)-Vitisin A and (-)-vitisin B showed strong anti-attachment activity agaist shells. Furthermore, (+)-vitisin C showed strong inhibition of the contractile responses of rabbit aorta in an endothelium-dependent manner by producing NO due to facilitate intracellular CAィイD12+ィエD1 mobilization in endothelial cells.

“巨峰”葡萄属葡萄的软木塞是从栽培者那里作为废物提供的。在寻找新的药用资源的过程中，软木塞受到了重视。软木的甲醇提取物得到了11个新的二苯乙烯四聚体、一个新的二苯乙烯三聚体、一个新的二苯乙烯二聚体以及许多已知的二苯乙烯低聚体.研究了已知的二苯乙烯二聚体和主要成分（+）-ε-viniferin对次要生物活性低聚二苯乙烯的生物发生反应。（+）-ε-viniferin的酸催化反应得到了三种碳骨架与（+）-ε-viniferin不同的二苯乙烯二聚体。（+）-ε-viniferin与辣根过氧化物酶和过氧化氢反应，得到（-）-vitisin B和（+）-vitisin C，均为二苯乙烯四聚体.（+）-Vitisin A和（-）-Vitisin B具有较强的抗贝壳附着活性。此外，（+）-Vitisin C通过促进内皮细胞内CA β D12+ CA β D1的动员而产生NO，以内皮依赖的方式强烈抑制兔主动脉的收缩反应。