Analysis of mechanical stress in lung cancer cells for therapeutic target search

分析肺癌细胞的机械应力以寻找治疗靶点

• 批准号: 15K09216
• 负责人: Kondo Masashi
• 金额: $ 3.08万
• 依托单位: Fujita Health University (2017)Nagoya University (2015-2016)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09216/
• 关键词: 肺癌; メカノバイオロジー

项目成果

Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells.

• DOI: 10.1002/cam4.412
• 发表时间: 2015-04
• 期刊: CANCER MEDICINE
• 影响因子: 4
• 作者: Yamashita, Ryo;Sato, Mitsuo;Kakumu, Tomohiko;Hase, Tetsunari;Yogo, Naoyuki;Maruyama, Eiichi;Sekido, Yoshitaka;Kondo, Masashi;Hasegawa, Yoshinori
• 通讯作者: Hasegawa, Yoshinori

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.

• DOI: 10.1111/cas.13602
• 发表时间: 2018-06
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Tanaka I;Sato M;Kato T;Goto D;Kakumu T;Miyazawa A;Yogo N;Hase T;Morise M;Sekido Y;Girard L;Minna JD;Byers LA;Heymach JV;Coombes KR;Kondo M;Hasegawa Y
• 通讯作者: Hasegawa Y

Cytochrome c oxidase subunit 5a (COX5A) is identified as a potential therapeutic target for lung cancer with high therapeutic index through a pooled shRNA screen

通过混合 shRNA 筛选，细胞色素 c 氧化酶亚基 5a (COX5A) 被确定为具有高治疗指数的肺癌潜在治疗靶点

• 发表时间: 2016
• 作者: 1.Toshio Kato;Mitsuo Sato;Masashi Kondo; Tomohiko Kakumu;Naoyuki Yogo;Tetsunari Hase;Masahiro Morise;John D Minna;Yoshinori Hasegawa
• 通讯作者: Yoshinori Hasegawa

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer.

• DOI: 10.1111/cas.13185
• 发表时间: 2017-04
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Kakumu T;Sato M;Goto D;Kato T;Yogo N;Hase T;Morise M;Fukui T;Yokoi K;Sekido Y;Girard L;Minna JD;Byers LA;Heymach JV;Coombes KR;Kondo M;Hasegawa Y
• 通讯作者: Hasegawa Y

Phase II Study of Carboplatin and Pemetrexed in Advanced EGFR-wild-type Non-squamous Non-small Cell Lung Cancer: The Central Japan Lung Study Group Trial 0906.

卡铂和培美曲塞治疗晚期 EGFR 野生型非鳞状非小细胞肺癌的 II 期研究：日本中部肺研究组试验 0906。

• 发表时间: 2016
• 期刊: Anticancer Res.
• 作者: Kimura T;Taniguchi H;Watanabe N;Saka H;Kogure Y;Shindo J;Ogasawara T;Kojima E;Hasegawa Y;Yamamoto M;Suzuki R;Ando M;Kondo M;Saito H
• 通讯作者: Saito H