The examination of AD pathology from the perspective of the astrocyte-neuron interaction: the participation of IGFBP-3 released by astrocytes.

从星形胶质细胞-神经元相互作用角度审视AD病理：星形胶质细胞释放的IGFBP-3的参与

• 批准号: 26461270
• 负责人: Uemura Kengo
• 金额: $ 3.08万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461270/
• 关键词: 神経分子病態学; 認知症; 脳、神経

项目成果

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.

• DOI: 10.1186/s13041-015-0174-2
• 发表时间: 2015-12-04
• 期刊: Molecular brain
• 影响因子: 3.6
• 作者: Watanabe K;Uemura K;Asada M;Maesako M;Akiyama H;Shimohama S;Takahashi R;Kinoshita A
• 通讯作者: Kinoshita A

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

高脂肪饮食通过促进β地点App裂解酶1/衔接蛋白2/网格蛋白复合物的形成来增强淀粉样蛋白前体蛋白（APP）的β地点切割。

• DOI: 10.1371/journal.pone.0131199
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Maesako M;Uemura M;Tashiro Y;Sasaki K;Watanabe K;Noda Y;Ueda K;Asada-Utsugi M;Kubota M;Okawa K;Ihara M;Shimohama S;Uemura K;Kinoshita A
• 通讯作者: Kinoshita A

Idiopathic Normal Pressure Hydrocephalus has a Different Cerebrospinal Fluid Biomarker Profile from Alzheimer's Disease

• DOI: 10.3233/jad-142622
• 发表时间: 2015-01-01
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Jingami, Naoto;Asada-Utsugi, Megumi;Kinoshita, Ayae
• 通讯作者: Kinoshita, Ayae