Chest/head circumference ratio at birth and childhood non-alcoholic fatty liver disease

在本财政年度，我们的主要重点是招募研究参与者。我们最初的目标是招募2500名儿童，但由于COVID-19的爆发，我们只能招募2190名儿童，占预期样本量的87. 6%。我们成功地从招募的儿童中收集了全面的健康信息，使我们能够对他们的整体身体发育和健康状况进行有价值的洞察。测量身高、体重、腰围、身体脂肪成分和血压，为他们的身体发育提供重要数据。还收集了参与者的血液样本，以分析一系列生物标志物。具体而言，我们测量了血清肝酶丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST）和γ-谷氨酰转移酶（GGT）的水平。这些酶在评估肝功能方面起着至关重要的作用，可以帮助检测任何潜在的肝脏疾病，特别是儿童非酒精性脂肪肝（NAFLD）。除了肝酶，我们还分析了脂质（甘油三酯、总胆固醇、HDL胆固醇、LDL胆固醇）、HbA 1c、脂联素、尿酸、肌酐和hs-CRP，因为这些标志物提供了与代谢健康相关的有价值的信息，并提供了对发生心脏代谢疾病风险的见解。

During the fiscal year, our primary focus was on the recruitment of study participants. Our initial target was to recruit 2500 children; however, due to the outbreak of COVID-19, we were only able to recruit 2190 children, which represents 87.6% of our intended sample size.We successfully collected comprehensive health information from the recruited children, allowing us to gain valuable insights into their overall physical growth and health status. Measurement of height, weight, waist circumference, body fat composition, and blood pressure were taken, providing important data on their physical development.Blood samples were also collected from the participants to analyze a range of biomarkers. Specifically, we measured serum levels of liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). These enzymes play a crucial role in assessing liver function and can help detect any potential liver disorders, particularly childhood non-alcoholic fatty liver disease (NAFLD). In addition to liver enzymes, we analyzed lipids (triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol), HbA1c, adiponectin, uric acid, creatinine, and hs-CRP as these markers offer valuable information related to metabolic health and provide insights into the risk of developing cardio-metabolic disorders.