Nanomedicine-based Chemo-Immunotherapy for the Treatment of Pediatric Brain Cancer

基于纳米药物的化学免疫疗法治疗小儿脑癌

基本信息

批准号：
22K12833
负责人：
劉学瑩
金额：
$ 2.66万
依托单位：
Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2022
资助国家：
日本
起止时间：
2022-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K12833/
关键词：
Nanomedicine chemo-immunotherapy medulloblastoma childhood cancers Chemo-immunotherapy pH-triggered Medulloblastoma

项目摘要

For this project, we proposed to generate and validate a syngeneic mouse model of medulloblastoma and understand the potential of a tumor pH-sensitive NM loaded with ICD-inducing drug modulating tumor immune environment against MB. Towards these aims, we managed to achieve the following research outcomes-Generate and validate a syngeneic mouse model of medulloblastoma (MB) - Dr. Robert Wechsler-Reya's laboratory at Sanford Burnham Prebys Medical Discovery Institute, CA, United States, established several MB syngeneic models. One of the collaborating investigators (Co-I), Dr. Sabina Quader, could successfully initiate a research collaboration with Dr. Wechsler-Reya. Through this collaboration we created a syngeneic mouse model of MB in our laboratory. We consider this a significant advancement in our MB-related research, as developing a syngeneic mouse model is critical for immune-related studies against MB.Collect preliminary research results using tumor pH-sensitive NM loaded with ICD-inducing drug against MB syngeneic model- We have successfully completed our preliminary research studies using tumor pH-sensitive NM loaded with ICD-inducing drug against MB syngeneic model. Based on the results of these studies, we are now moving on to the next phase of studies, where we are considering examining the potential of using immune checkpoint inhibitors.

对于这个项目，我们提议生成和验证髓母细胞瘤的合成小鼠模型，并了解肿瘤pH敏感的NM的潜力，该肿瘤pH敏感的NM载有ICD诱导药物，可调节针对MB的肿瘤免疫环境。为了这些目标，我们设法实现了以下研究结果生成的结果，并验证了髓母细胞瘤（MB）的综合小鼠模型 - 美国加利福尼亚州桑福德·伯纳姆·伯纳姆·伯斯医学医学研究所的Robert Wechsler-Reya博士实验室建立了几种MB合成模型。合作调查员之一（CO-I），Sabina Quader博士，可以成功地与Wechsler-Reya博士进行研究合作。通过这种合作，我们在我们的实验室中创建了MB的合成小鼠模型。我们认为这在与MB相关的研究中取得了重大进步，因为开发一种合成小鼠模型对于针对MB的免疫相关研究至关重要。收集的初步研究结果使用肿瘤pH敏感的NM，该肿瘤pH敏感性的NM用ICD诱导MB合素模型的ICD诱导药物 - 我们成功地完成了使用tumor phg-Sennm prage Icd Myd-prage nm rodict ICD MOND-prage nm-prage ICD MOND-prage nm positigation Moge-MB Syngeneic模型。基于这些研究的结果，我们现在正在进入下一阶段的研究，我们正在考虑检查使用免疫检查点抑制剂的潜力。