NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS
NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS
批准号:
LP0455769
负责人:
A/Prof Vivienne Reeve
金额:
$16.89万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-11-25 至 2008-01-11
中文摘要
该项目旨在使用小鼠中人类自身免疫性疾病的实验模型来测试由行业合作伙伴生产的发育抑制剂化合物,以对抗自身免疫的保护作用。 提出的小鼠模型将复制人类自身免疫性心肌病,系统性红斑狼疮和多发性硬化症,包括器官特异性和系统性自身免疫性疾病。 从这些化合物的抗氧化、抗炎和雌激素特性可以预期异黄酮的保护作用。
英文摘要
The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoid protection is anticipated from the antioxidant, anti-inflammatory and oestrogenic characteristics of these compounds/
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