Molecular mechanisms that regulate the kinetics of neurotransmitter release

调节神经递质释放动力学的分子机制

• 批准号: DP240102418
• 负责人: A/Prof Zhitao Hu
• 金额: $ 48.22万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102418
• 关键词: Molecular; mechanisms; regulate; kinetics; neurotransmitter

Information processing in the human brain plays important roles in normal behaviour and cognition, most of which require rapid and precisely timed neurotransmitter release. However, the molecular mechanisms that control the speed and timing of this release remain largely unclear. This research project will use a novel mix of electrophysiology, electron microscopy, genetics, biochemistry, and imaging to investigate how the speed of neurotransmitter release is controlled by the most important synaptic protein UNC-13 and its binding partners. This project expects to generate significant knowledge in the area of synaptic transmission. The outcomes will deepen our understanding of neuronal communication and information processing in the brain.

人类大脑中的信息处理在正常行为和认知中起着重要作用，其中大多数需要快速和精确定时的神经递质释放。然而，控制这种释放的速度和时间的分子机制在很大程度上仍然不清楚。该研究项目将使用电生理学，电子显微镜，遗传学，生物化学和成像的新组合来研究神经递质释放的速度是如何由最重要的突触蛋白E13及其结合伙伴控制的。该项目预计将产生突触传递领域的重要知识。这些结果将加深我们对大脑中神经元通信和信息处理的理解。