Molecular mechanisms that regulate the kinetics of neurotransmitter release

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Information processing in the human brain plays important roles in normal behaviour and cognition, most of which require rapid and precisely timed neurotransmitter release. However, the molecular mechanisms that control the speed and timing of this release remain largely unclear. This research project will use a novel mix of electrophysiology, electron microscopy, genetics, biochemistry, and imaging to investigate how the speed of neurotransmitter release is controlled by the most important synaptic protein UNC-13 and its binding partners. This project expects to generate significant knowledge in the area of synaptic transmission. The outcomes will deepen our understanding of neuronal communication and information processing in the brain.