Investigation on the Pathophysiology of the Earliest Primary Open-angle Glaucoma

在这项研究中，再次证实了眼底相机和眼睛之间的准确对准对于立体计时检查是至关重要的。为此，对立体计时眼底相机进行了改进，改变了监视器图案的比例，并将图案和角膜反射光与眼底图像叠加在胶片上。通过这种修改，可以更容易和准确地获得和检查对准。立体计时镜对视盘改变的随访研究发现，正常患者的视盘改变不明显，而高眼压和青光眼患者的视盘改变由轻到重。即使眼压控制良好的眼杯有轻微的变化，立体计时镜也能检测到，而常规立体摄影显示视野没有任何变化，杯也没有变化。我们注意到，立体计时器显示的杯子变化与错位导致的立体图像截然不同。随访期内杯子普遍增大，表现为半杯远、另半杯近的感觉。杯子的一小部分略有变化，给人一种遥远或接近的感觉。这些立体图像可以通过杯子中真实变化产生的双目视差来解释。这些立体图像不能被照片的方位旋转所抵消。从这些结果来看，立体计时镜可以说是早期发现青光眼视盘改变的有用方法。

In this research, it was reconfirmed that the accurate alignment between the fundus camera and the eye was essential on stereo-chronoscopy. For this purpose, the stereo-chronoscopic fundus camera was modified by changing the scale of the monitor pattern and by super-imposing the pattern and the light of corneal reflex with the fundus image onto the film. With this modification, the alignment could be obtained and checked more easily and accurately. The follow-up study on the optic disc change by stereo-chronoscopy revealed no change in eyes of the normal patients but changes from slight to severe degree in the cup of ocular hypertensive and glaucomatous eyes. Even slight changes in the cup of the eye with well controlled intraocular pressure could be detected by stereo-chronoscopy, while those eyes did not show any change in visual field and any change in the cup with usual stereophotographs. We noticed that the changes in the cup show quite different stereoscopic images by stereo-chronoscopy from those caused by misalignment. The cup generally enlarged during the follow-up period shows the impression of remoteness in the one half of the cup and the impression of nearness in the other half of the cup. The cup with a small part slightly changed gives the impression of remoteness or nearness. These stereoscopic images can be interpreted by the binocular parallax which the true changes in the cup produce. These stereoscopic images could not be nulled by azimuthal rotation of the photographs.From these results, stereo-chronoscopy can be said usefull in early detection of the glaucomatous changes in the optic disc.