The effect of volatile anesthetics on the physico-chemical aspects and the functions of model- and bio-membrane. ---- On the mechanism of anesthesia.

点击翻译按钮获取中文摘要

On the molecular site of volatile anesthetic action, discussions were concentrated from the several points of view in the annual open conference on the mechanism of anesthesia, and in the annual closed shop meeting constituted from 14 investigators who have engaged in the fundamental study on anesthetic action. The concrete themes discussed were those ; on the membrane which is useful for thestudy on the mechanism, on the changes of charge and hydration in the phase boundary of membrane, and on the compression study and partition of ansthetics in the membrane and the membrane boundary.Through these dosciussion, we approached to the common opinion that the binding of volatile anesthetics to action site is of non-specific type, even though the report that there is a saturable binding site related to anesthesia was presented ( Evers,A.S. et al.:Nature 328,157-160,1987 ). Saturable binding mode is seen in atypical Langmuir adsorption of volatile anesthetics which is non-specific.