An experimental study on chronic compression injury of the spinal cord due to kyphotic deformity.

后凸畸形引起的脊髓慢性压迫损伤的实验研究。

• 批准号: 60440071
• 负责人: ONOMURA Toshinobu
• 金额: $ 12.99万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60440071/
• 关键词: Spinal distraction; spinal cord evoked potentials; Spinal cord blood flow; experimental compression of spinal cord; Kyphotic deformity; 脊柱後弯変形; 圧迫性脊髄麻痺

In order to evaluate the influence of the traction on the spinal cord function due to ischemic changes of the spinal cord, the spinal cord blood flow and the spinal cord evoked potentials in response to strong and weak stimulation was measured in mature rabbits under spinal column traction. In animals subjected to a traction corresponding to approximately 32% of the vertebral body length, the amplitude of evoked potential in weak stimulation increased transiently, whereas the amplitude in strong stimulation declined slowly. The blood flow at this time was decreased to 10ml/min/100g, suggesting spinal cord dysfunction. For the diagnosis of spinal cord injury due to ischemia, observation of the amplitude changes in response to weak stimulus appeared to be indispensable even if the amplitude changes in strong stimulation remained within a safe range.By posterior ( posterior method ) or anterior ( anterior method ) manipulation of the rabbit spinal column, an animal model with kyphotic def … More ormity with a constant pressure on the spinal cord was prepared. The dynamic compression by the spinal deformity appeared to be the major cause of spinal cord inixiry, whereas the static pressure appeared to be responsible for the injury in the anterior method. None of these models showed paralysis, probably serving as the model for the initial stage of chronic compression spinal cord damage. However, in all cases, measurement of the spinal cord evoked potential revealed some potential changes. This method thus appeared to be very useful for the detection of subclinical spinal cord injury due to chronic compression. The prolongation of conduction time was more pronounced in the posterior method, although the decrease in amplitude appeared to be more pronounced in the anterior method. It is considered that demyelination is readily occurred on dynamic compression such as the posterior method, while the static compression as in the anterior method tends to cause axonal degeneration. Qualitative difference in spinal cord injury may be caused by the differences in the mode of compression itself, such as the presence or absence of the mobility of the kyphotic portion, or by differences in the secondary factors associated with each compression modality. Less

为探讨牵引对脊髓缺血性改变所致脊髓功能的影响，对成年兔在脊柱牵引条件下进行了脊髓血流量和脊髓诱发电位的测定。在受到相当于椎体长度约32%的牵引的动物中，弱刺激下的诱发电位幅度一过性增加，而强刺激下的幅度缓慢下降。此时血流量降至10ml/min/100g，提示脊髓功能障碍。对于缺血性脊髓损伤的诊断，即使强刺激下的幅度变化保持在安全范围内，观察对弱刺激的反应幅度的变化似乎也是必不可少的。通过后(后)法或前(前)法手法治疗兔脊柱后凸畸形…动物模型准备了对脊髓施加恒定压力的更多椎体。脊柱畸形造成的动态压缩是脊髓损伤的主要原因，而前路手术的损伤主要是静力压迫造成的。这些模型都没有表现出瘫痪，可能是慢性压迫脊髓损伤的初始阶段的模型。然而，在所有病例中，脊髓诱发电位的测量都显示了一些潜在的变化。因此，这种方法对于检测慢性压迫引起的亚临床脊髓损伤是非常有用的。传导时间的延长在后路更为明显，而波幅的降低似乎在前路更为明显。认为后路等动态加压易发生脱髓鞘，而前路等静态加压易导致轴突变性。脊髓损伤的性质差异可能是由于受压方式本身的不同，如后凸部分是否有活动能力，或与每种受压方式相关的次要因素的差异所致。较少

项目成果

小林一朗: 第2回 日本整形外科学会基礎学術集会.

小林一郎：日本骨科学会第二次基本学术会议。

中島幹雄: "脊柱後弯変形による脊髄圧迫障害に関する実験的研究ー第3報ー動的あるいは静的圧迫による脊髄誘発電位の変化" 日本整形外科学会誌. 63(7). S-1044 (1989)

Mikio Nakajima：“后凸畸形引起的脊髓压迫损伤的实验研究 - 第三次报告 - 动态或静态压迫引起的脊髓诱发电位的变化”日本骨科学会杂志 63(7) (1989)。

Ichiro KOBAYASHI: "The effect of spinal traction on spinal cord evoked potential with special reference to spinal cord blood flow" J.Jpn.Orthop.Assoc., 62(2):S-170, 1988.

Ichiro KOBAYASHI：“脊柱牵引对脊髓诱发电位的影响，特别是脊髓血流”J.Jpn.Orthop.Assoc.，62(2)：S-170，1988。

Mikio NAKAJIMA: "A study on the experimental kyphotic deformity of rabbits -1st. report" Cent.Jpn.Orthop.Traumat., 31:757-762, 1988.

Mikio NAKAJIMA：“兔子实验性后凸畸形的研究 -1 报告”Cent.Jpn.Orthop.Traumat.，31：757-762，1988。

中島幹雄: "脊柱後弯変形による脊髄圧迫障害に関する実験的研究ー第2報ー後方あるいは前方操作による後弯変形" 中部日本整形外科災害外科学会誌. 32. 141-144 (1989)

Mikio Nakajima：“后凸畸形引起的脊髓压迫损伤的实验研究 - 第 2 次报告 - 后侧或前侧操作引起的后凸畸形” 日本中部整形外科和灾难外科学会杂志 32. 141-144 (1989)。