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Effect of growth hormone on mammary gland growth and lactation in mice with special reference of the relation with prolactin.

生长激素对小鼠乳腺生长和泌乳的影响，特别是与催乳素的关系。

基本信息

批准号：
60560292
负责人：
NAGASAWA Hiroshi
金额：
$ 1.28万
依托单位：
Meiji University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60560292/
关键词：
GH mammary growth mammary tumorigenesis mouse prolactin マウスソマトスタチン

项目摘要

1. GH and Mammary Gland Growth1) GH and normal mammary gland growth: Twice daily injections of 5 or 50 ng SMS to C3H/He virgin mice between 25 and 55 days of age resulted in a significant inhibition of normal mammary gland growth associated with the reduced plasma GH level. Similar results were also obtained by the neonatal single injection of 4 mg monosodium glutamate (MSG) to SHN female mice. Meanwhile, plasma prolactin (PRL) level and the pattern of estrous cycles were affected little by either treatment. There was the significant simple correlation between plasma GH level and normal mammary gland growth, but not the partial correlation when plasma PRL level was fixed.2) GH and preneolastic mammary hyperplastic alveolar nodule (HAN) formation: Single neonatal MSG treatment inhibited HAN formation. However, GH level had neither single nor partial correlation with HAN formation.3) GH and spontaneous mammary tumor development: Spontaneous mammary tumor development was affected little by reduced plasma GH level by MSG.2. GH and lactationIn C3H/He mice, chronic decline of plasma GH level by twice daily injections of 50 ng SMS suppressed normal mammary gland growth on day 12 of lactation, however, there was no difference in lactational performance between the SMS-treated and the control groups.All findings strongly suggest that while GH is an important hormone for normal mammary gland growth and lactation, its role is often masked by the other mammotropic hormones, PRL.

1. GH 和乳腺生长 1) GH 和正常乳腺生长：每天两次向 25 至 55 日龄的 C3H/He 处女小鼠注射 5 或 50 ng SMS，导致与血浆 GH 水平降低相关的正常乳腺生长显着抑制。给SHN雌性小鼠新生儿单次注射4mg味精（MSG）也获得了类似的结果。同时，血浆催乳素（PRL）水平和动情周期模式受这两种治疗的影响很小。血浆GH水平与正常乳腺生长之间存在显着的简单相关性，但当血浆PRL水平固定时，不存在部分相关性。2）GH与新生前乳腺增生性肺泡结节（HAN）的形成：单用味精治疗新生儿可抑制HAN的形成。然而，GH水平与HAN的形成既不单一也不部分相关。3）GH和自发性乳腺肿瘤的发生：MSG降低血浆GH水平对自发性乳腺肿瘤的发生影响很小。2． GH 和哺乳期在 C3H/He 小鼠中，每天两次注射 50 ng SMS 导致血浆 GH 水平慢性下降，从而抑制了哺乳期第 12 天的正常乳腺生长，然而，SMS 治疗组和对照组之间的哺乳表现没有差异。所有研究结果强烈表明，虽然 GH 是正常乳腺生长和哺乳的重要激素，但其作用常常被其他激素所掩盖。促乳腺激素，PRL。