Studies on the membrane complement inhibitors by use of reconstituted liposome membrane

将红细胞膜糖蛋白掺入人工合成的脂质体膜中，分析其对补体替代途径的影响。所得结果如下：1)来自豚鼠红细胞的糖蛋白（GP）抑制豚鼠补体的替代途径。2)对于抑制作用，糖蛋白需要存在于补体激活发生的同一膜上。3)膜糖蛋白已被证明可以抑制替代补体途径的扩增反应。4)通过蛋白酶- k处理，糖蛋白对脂质体膜的抑制能力被破坏。

Glycoproteins from erythrocyte membrane were incorporated into the artificially reconstituted liposome membranes and their effect on the alternative complement pathway was analysed. The results obteined are as follows;1) Glycoprotein(GP) from guinea pig erythrocytes inhibits the alternative pathway of guinea pig complement.2) For the inhibition, the glycoprotein was required to be present on the same membrane where complement activation occured.3) The membrane glycoprotein has been shown to inhibit the amplification reaction of the alternative complement pathway.4) The inhibitory capacity of the glycoprotein on the liposome membrane was aborished by proteinase-K treatment.