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Experimental Studies on Malignant Fibrous Histiocytomd

恶性纤维组织细胞瘤的实验研究

基本信息

批准号：
60570701
负责人：
MII Yoshio
金额：
$ 0.9万
依托单位：
Nara Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

项目摘要

In order to clarify the characteristic behavor and the efficacy of chemotherapeutic agents between histological subtypes of malignant fibrous histiocytoma (MFH), we performed experimental studies using transplantable line of MFH induced by 4-hydroxyaminoquinoline 1-oxide in Fischer 344 rats. The following results were obtained.1. Individual MFH-fibrous, giant cell and myxoid subtypes, induced by 4-HAQO were successfully transplanted serially into syngeneic rats resulting in high transplantability.2. It is poshible to produce dose- and time- dependent intravenous injection of tumor cell suspensions prepared from giant cell and myxoid subtypes of MFH.3. Chemotherapeutic agents, adriamycin (ADM), cis-dichlorodiamine platinum II (CDDP) cyclophosphamide (CPM) were effective in suprressing the growth of giant cell and myxoid subtypes of MFH serially transplanted into subcutaneous tissue.4. ADM, CDDP and CPM inhibited the lung nodules by intravenous injection of tumor cell suspension prepared from giant cell subtypes of MFH but only CPM was effective in reducing number of lung nodules induced by myxoid subtype.5. The metastatic potential of myxoid subtype of MFH was enhanced with in vivo selection.6. These results indicate that the transplantable and metastatic abilities of each subtype of MFH are useful in studying the characteristic behavor and efficacy of chemotherapeutic agents and may give basic information to MFH in humans.

为了阐明化疗药物在恶性纤维组织细胞瘤（MFH）组织学亚型间的特点、行为和疗效，我们在Fischer 344大鼠身上采用4-羟氨基喹啉1-氧化物诱导的MFH可移植细胞系进行了实验研究。得到了以下结果：4-HAQO诱导的单个mfh -纤维、巨细胞和黏液样亚型相继移植到同基因大鼠体内，具有较高的可移植性。由MFH.3的巨细胞和黏液样亚型制备的肿瘤细胞悬浮液有可能产生剂量依赖性和时间依赖性静脉注射。化疗药物阿霉素（ADM）、顺式二氯二胺铂II （CDDP）环磷酰胺（CPM）可有效抑制MFH巨细胞和黏液样亚型相继移植皮下组织的生长。通过静脉注射MFH巨细胞亚型制备的肿瘤细胞悬液，ADM、CDDP和CPM均能抑制肺结节，但只有CPM能有效减少黏液样亚型诱导的肺结节数量。黏液样亚型MFH的转移潜力通过体内筛选增强。这些结果表明，MFH各亚型的移植和转移能力有助于研究化疗药物的特征行为和疗效，并可能为人类MFH提供基本信息。