Experimental Studies on Malignant Fibrous Histiocytomd

为了阐明恶性纤维组织细胞瘤(MFH)组织学亚型之间的行为特点和化疗药物的疗效，我们用4-羟氨基喹啉-1-氧化物诱导的MFH可移植系在344只大鼠身上进行了实验研究。取得了以下研究成果：1.结论：1.4-HAQO诱导的单个MFH-纤维型、巨细胞型和粘液型成功地连续移植到同基因大鼠体内，具有较高的可移植性。它可以产生剂量和时间依赖的静脉注射从巨细胞和粘液亚型MFH.3制备的肿瘤细胞悬浮液。化疗药物阿霉素(ADM)、顺式二氯二胺铂II(CDDP)、环磷酰胺(CPM)对连续皮下移植的巨细胞和黏液亚型MFH的生长有明显的抑制作用。ADM、CDDP和CPM静脉注射巨细胞亚型MFH制备的肿瘤细胞悬液对肺结节有抑制作用，但仅CPM能有效减少粘液亚型诱导的肺结节数目。体内选择可增强粘液型MFH的转移潜能。这些结果表明，MFH各亚型的移植和转移能力有助于研究化疗药物的特性、行为和疗效，并可能为人类MFH的研究提供基础信息。

In order to clarify the characteristic behavor and the efficacy of chemotherapeutic agents between histological subtypes of malignant fibrous histiocytoma (MFH), we performed experimental studies using transplantable line of MFH induced by 4-hydroxyaminoquinoline 1-oxide in Fischer 344 rats. The following results were obtained.1. Individual MFH-fibrous, giant cell and myxoid subtypes, induced by 4-HAQO were successfully transplanted serially into syngeneic rats resulting in high transplantability.2. It is poshible to produce dose- and time- dependent intravenous injection of tumor cell suspensions prepared from giant cell and myxoid subtypes of MFH.3. Chemotherapeutic agents, adriamycin (ADM), cis-dichlorodiamine platinum II (CDDP) cyclophosphamide (CPM) were effective in suprressing the growth of giant cell and myxoid subtypes of MFH serially transplanted into subcutaneous tissue.4. ADM, CDDP and CPM inhibited the lung nodules by intravenous injection of tumor cell suspension prepared from giant cell subtypes of MFH but only CPM was effective in reducing number of lung nodules induced by myxoid subtype.5. The metastatic potential of myxoid subtype of MFH was enhanced with in vivo selection.6. These results indicate that the transplantable and metastatic abilities of each subtype of MFH are useful in studying the characteristic behavor and efficacy of chemotherapeutic agents and may give basic information to MFH in humans.