The Redox Reaction System of the Iron Porphyrin Complexes.

本研究的最终目的是了解由铁卟啉配合物组成的氧化还原反应体系，这是生物血红素蛋白体系的相关模型。本基金资助的两年研究包括邻位取代芳基卟啉异构体的合成、分离和氧化还原反应体系的考察。由于对晶体产物的结构研究已取得成功，有关锌卟啉阻转异构体的报道已作为本工作的一部分发表（参考文献1-3）。对铁配合物的光谱进行了实验研究，重点研究了不同吡啶类化合物与Fe <（OEP）^+>配位时的光谱变化。在本研究中，我们观察到<III><II>当配体在分子中具有=CH-NH-基团时，例如吡啶胺，在卟啉中Fe（）还原为Fe（）。本研究的更具体结果将在日本药学会第107次会议上公布。

The ultimate purpose of this research in the understanding for the redox reaction system consisting of iron porphyrin complexes which are relevant models for the biological hemoprotein system. The two-year study aided by this fund has involved the synthesis and isolation of various isomers of ortho-substituted arylporphyrin and the survey for the redox reaction system. The reports concerning the atropisomers of zinc porphyrin have been published as the part of this work (ref. 1-3) since the structural study has been successful on the crystal products. Experiments on those of the iron complexes also carried out and the study is now focusing to the the spectral changes on the coordination of various pyridines to Fe <(OEP)^+> . In this study, we observed the reduction reaction of Fe( <III> ) to Fe( <II> ) in the porphyrin when the ligand has the =CH-NH- group in the molecule, e.g. picolylamines. The more specific results on this study will be presented at the 107th meeting of the Pharm. Soc. Jpn..