Researched of biological adaptation and physical fitness at high-altitude environment.

1.对5名医学生在八岳山（2,400 m）的整个上升和下降过程中的心率（HR）进行了测量和分析。还在海拔600 m（基线）、1，800 m和2，400 m处进行了一些调查。以高中生和家庭主妇为研究对象，在跑台上（低于180次/分，HR）跑步时，测定心率、通气量、氧摄入量和二氧化碳排出量。通过分析这些数据，估计最大氧耗量（VO 2-max），并证明VO 2-max更依赖于通气量而不是HR.以心率指数（HR）考察大鼠对高原的耐受能力。结果表明，该虫的存活期不仅与海拔高度有关，而且与温度有关，高温下存活期缩短，低温下存活期延长。根据对适应高海拔（Sakai）的动物鼠兔的研究，未发现肺动脉高压，并且显示出低血细胞比容，尽管肺动脉高压在非适应动物中很常见。高原适应不良时，可发生高原反应或高原肺水肿。DBcAMP应用于肺动脉栓塞后，可明显缓解症状.在高原低温条件下，大鼠产热先增加。在长时间暴露于这种条件下，热损失的预防机制发展。褐色脂肪组织在产热中起重要作用，柳平等人发现在营养充足的情况下，该组织的重量会增加.通过局部冷暴露，冷诱导兔耳血管出现血管振荡。针刺使这些振荡变得巨大。它可以被认为是冻伤的防御反应在攀登（竹冈）. 1987年11月在松本召开的国际高原医学学术讨论会是对这些研究的总结。日本和外国研究人员讨论了有关高海拔医学和生物学。

1. Heart rates (HR) of five medical students were measured and analyzed throughout the ascent and descent Mt Yatsugatake (2,400 m). Some investigations were also made at the altitudes of 600 m (beseline), 1,800 m, and 2,400 m. By using senior high school students and housewives, the HR. ventilation, oxygen intake, and carbon dioxide output were measured during the running on a treadmill (under 180 beats / min, HR). Maximal oxygen consumption (VO2-max) was estimated by analyzing these data and the fact that VO2-max depends more on ventilation than HR was proved.2. Tolerant ability of rats to high altitude was investigated with HR index. It was concluded that the servival time depended on not only altitude but temperature, since the time was shortened in high temperature and prolonged in low one. From the study of Pika that is an animal adapted to high altitude (Sakai) the pulmonary hypertension was not found and the low hematocrit was shown although pulmonary hypertension was common in non-adapted animals. When maladaptation occurred at high altitude, mountain sickness or high altitude pulmonary edema followed. The remission of symptoms was observed when DBcAMP was applied to the lung preparation.3. For the low temperature at high altitude, heat production in rats increased at first. Under prolonged exposure to such condition, the preventive mechanism of heat loss developed. Brown adipose tisse plays an important role for heat production, and the increase of this tissue weight under sufficient nutrition was found by Yanagidaira.4. By local cold exposure, cold induced vasooscillation appeared in rabbit-ear vessels. Needle puncture made these oscillations gigantic. It can be considered as defensive reactions of frostbite in climbing (Takeoka).5. As a summary of these researches, International Symposium of High-altitude Medical Science was held in Novmber 1987 in Matsumoto. Japan and foreign researchers discussed about high-altitude medicine and biology.