Life Function and the Most Advanced Organic Chemistry

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(1) Bioactive compounds with novel structures- Several bioactive natural products have been isolated from marine sponges and octocoral. Cyclonucleosides, (-)-bulgecinine, fumitremergin B, isocarbacyclin and their analogues have synthesized, aiming at new substances with improved bioactivities. A fluoro derivatives of arachidonic acid have been synthesized and its biotransformation was studied. Syntheses of useful ligands for photoaffinity laveling and affinity chromatography of receptors have been examined. Also studied was the chemical modification of DNA which causes mutation.(2) Development of new synthetic methodologies for bioactive molecules - New methods for the deprotection for peptide synthesis and macrolide synthesis have been developed. A new dienophil was invented for C-nucleoside synthesis. Synthesis of vitamine D and related compounds have been studied. Chiral bases, metal complex catalysts, useful methods for asymmetric deprotonation and asymmetric aldol reaction have been applied for natural product synthesis. Polycyclic aromatic compounds and crowned p-benzoquinones have been synthesized and their functions have been investigated. Chiral synthons have been created by enzymatic hydrolysis of symmetric diesters based on the symmetrization-asymmetrization concept.