家畜の消化管免疫機構に関する研究

家畜胃肠免疫系统研究

• 批准号: 61560330
• 负责人: 橋本 善春
• 金额: $ 1.22万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61560330/
• 关键词: 免疫; 家畜; 消化管; リンパ組織

1.研究の概要、実施方法および経過等:ブタとニワトリについて、消化管付属リンパ組織の構築とそれに含まれる諸細胞の動態および免疫グロブリン(Igs)の胎盤内局在について以下により検討した。ブタでは空腸リンパ節内の動脈およびリンパ管の走行を節内におけるリンパ組織の分布と対応させながら観察し、併せて消化管内分泌細胞の分布とそれらの出現頻度を検索した。ニワトリでは上部消化管および気道に付属するリンパ組織の分化およびGlobule leucocytesの細胞傷害機構について検討した。2.研究成果の概要:ブタ空腸リンパ節の動脈は梁柱の走行にあわせて分岐し、皮・髄質様組織内において毛細血管網を形成していた。輸出リンパ管は多くのものが輸出門からよりも輸入門周囲から派出しており、他種家畜のそれとは方向性と分布様式において異なっていた。ブタの消化管粘膜上皮内には計12種類の内分泌細胞が同定され、これらは幽門腺部,十二指腸部,直腸部に高頻度に出現する傾向がみとめられた。ニワトリ上部消化管壁には食道扁桃が、気道では膜性気管支部のリンパ小節群が孵化後によく発達し、IgG,IgA含有細胞やGlobule leucocytesも出現していたことから、当該部位はニワトリの粘膜を介する免疫防御機構の中で重要と考えられた。3.研究成果の今後の活用等:本研究で得られた結果を以下の研究に活用する。1)家畜の消化管付属リンパ組織とリンパ節間の細胞交通様式、2)家畜胎仔の消化管分化・発達にともなう内分泌細胞の関与、3)家禽粘膜免疫機構におけるT・B細胞の関与、4)魚類免疫機構の細胞構築。

1. The summary of the study, the application of the method, and so on: the digestive tract, the tissue of the digestive tract, and so on, the summary of the study, the application of the method, etc., the digestive tract, the tissue of the digestive tract, the tissue of the digestive tract, the cell cycle, the immune system (Igs), and so on. The distribution of tissue in the digestive tract, the distribution of endocrine cells in the digestive tract, the distribution of endocrine cells in the digestive tract, the distribution of endocrine cells in the digestive tract. The upper digestive tract is located in the upper digestive tract. The tissue is differentiated and the Globule leucocytes cell damage mechanism is used to prevent the infection. two。 Summary of the research results: the movement of the beam and column, the bifurcation and the formation of the hair vascular network in the skin group. Out-of-the-door traffic control, multi-vehicle transportation, door-to-door distribution and distribution of directionality of other kinds of livestock and other kinds of livestock are distributed throughout the week. The endocrine cells in the mucosal epithelium of the digestive tract were the same as those in the pyloric glands, twelve fingers, and the straight portions. The upper digestive wall of the esophagus contains almond, the branch of the membranous duct of the esophagus, and the branch of the membranous duct of the esophagus. After hatching, the small population of the digestive tract has been detected after hatching, and the presence of cellular Globule leucocytes has been found in this part of the digestive tract. When the mucous membrane in this part of the digestive tract is involved in the immune defense mechanism, it is important to test it. 3. The results of the study are as follows: the results of this study are as follows: the results of this study are as follows. The main results are as follows: 1) the digestive tract of domestic animals is divided into two groups: 1) the digestive tract of domestic animals, 2) the differentiation of the digestive tract of livestock fetal babies, the endocrine cysts, 3) the T B cells of poultry mucosal immune organs, and 4) the immune organs of other immune organs.

项目成果

ARAI,N.: Japanese Journal of Veterinary Science. 49. (1987)

ARAI,N.：日本兽医科学杂志。

HOSHI,N.: Japanese Journal of Veterinary Science. 49. (1987)

HOSHI,N.：日本兽医科学杂志。