Intraepithelial Lymph Spaces in Correlation between Their Development of Three Dimensional Structure and Epithelial Differentiation.

上皮内淋巴空间三维结构发育与上皮分化之间的相关性。

• 批准号: 61570021
• 负责人: MIYOSHI Masayuki
• 金额: $ 1.54万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570021/
• 关键词: Intraepithelial Lymph Space; Cortu; s Organ; Intestinal Epithelium; Colon; Ulcerative Colitis; Fabricius; 腎乳頭間質細胞; 腸管上皮

The three dicensional structure of the intercellular space was ecamined under the scanning and transmission electron microscope (SEM & TEM) in verious kinds of epithelia.(1) In the corri's organ,the nerve fibers extended freely in the expanded epithelial spaces containing the lymph,whireas the nerve terminals on the hair cells were covered with cytoplasmic processes of phalangeal cells. The present study revealed the surface structure of nerve terminals and their arrangement on the hair cells after removal of phalangeal cell processes.(2) The inrerglandular epithelium of the colon was also equipped with intraepithelial spaces in a chsnnel system. The structure of the spaces was essentially aimilr to that in the small intestine. SEM and TEM examination of biopsy materials from patients in the ulcerative colitis indicated the existence of expanded intercellular space which contained the blood plasm and erythrocytes in masses. The infiltration of the blood from broken vessels into the native epithelial lymph space caused the tissue edema,leading to the erosion and ulcer of the colon mucous membrane.(3) The covering epithelial cells of the lymph nodules in the Fabricius' bursa were situated on lamellae of epithelial reticular cells. The reticular cells were attanged in a fashion of a wheel. The epithelial lamellae may be for percolation of absorbed materials.

用扫描电镜和透射电镜观察了不同类型上皮细胞的细胞间隙三维结构。(1)在科里器内，神经纤维在扩张的上皮间隙内自由延伸，毛细胞上的神经末梢被指细胞的胞质突起覆盖。本研究揭示了去除指细胞突起后神经末梢的表面结构及其在毛细胞上的排列。(2)结肠腺内上皮也有上皮内间隙。这些间隙的结构基本上类似于小肠的结构。溃疡性结肠炎患者活检组织的扫描电镜和透射电镜观察表明，细胞间隙扩大，其中含有大量的血浆和红细胞。破裂血管的血液渗入天然上皮淋巴间隙，引起组织水肿，导致结肠粘膜糜烂和溃疡。(3)腔上囊淋巴结的覆盖上皮细胞位于上皮网状细胞层上。网状细胞呈轮子状排列。上皮层可用于吸收物质的渗透。

项目成果

Masayuki Miyoshi,Hisanori Nishizono and Keisuke Hokazono: "Intercellular Spaces in the Interglandular Epithelium of the Rabbit Colon"

Masayuki Miyoshi、Hisanori Nishizono 和 Keisuke Hokazono：“兔结肠腺间上皮细胞间隙”

Hisanori Nishizono and Keisuke Hokazono: "Histological Changes of Mucosal Layer in Ulcerative Colitis - Scanning and Transmission Electron Microscopic Study - (in Japanese)"

Hisanori Nishizono 和 Keisuke Hokazono：“溃疡性结肠炎粘膜层的组织学变化 - 扫描和透射电子显微镜研究 -（日语）”

三好萬佐行: in preparation.

三好万斋之：正在准备中。

三好萬佐行: 病態生理. 5. 557-560 (1986)

三好万斋之：病理生理学。5. 557-560 (1986)

Masayuki Miyoshi: "Reticular Framework - Scanning Electron Microscopy - (in Japanese)" Electron-Microscopy. 21. 201-206 (1987)

Masayuki Miyoshi：“网状框架 - 扫描电子显微镜 -（日语）”电子显微镜。