Studies on the effect of gastro-intestinal, pancreatic and cardiac hormones on the efferent nerve activity of the autonomic nerve.

研究胃肠、胰腺和心脏激素对自主神经传出神经活动的影响。

• 批准号: 61570083
• 负责人: HIRANO Tetsuo
• 金额: $ 1.34万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570083/
• 关键词: Gastrin; CCK; Somatostatin; ANP; Autonomic nervous system; 迷走神経; 遠心性活動; ペンタガストリン; CCK-8; 迷走神経遠心性活動

Under anaesthesia (urethane 500-800 mg/kg and chloralose 40-70mg/kg), effect of i.v. administration of pentagastrin, CCK-8, somatostatin and ANP on efferent activity of autonomic nerve was observed in rats.An increase in activity was observed in gastric branch of vagus nerve following injection of pentagastrin, and that in pancreatic branch of vagus nerve after injection of CCK-8.A decrease in activity was observed in gastric, hepatic and pancreatic branch of vagus nerve following application of somatostation or ANP. ANP application also caused a suppression on activity of adrenal and renal sympathetic efferents. The smallest effective dose of these substances was 100pg.In decerebrated preparations no change in efferent activity was observed after administrations of these substances.The results indicate that neuropeptides such as pentagastrin, CCK-8, somatostatin and ANP released into venous circulation modulate autonomic outflows through hypothalamic neuronal networks surrounding with insufficient blood-brain barrier.

在麻醉状态下（聚氨酯500 ~ 800 mg/kg，氯氯蔗糖40 ~ 70mg/kg），观察五宫泌素、CCK-8、生长抑素和ANP对大鼠自主神经传出活动的影响。注射戊胃泌素后迷走神经胃支活性增高，注射CCK-8后迷走神经胰腺支活性增高。应用生长抑素或ANP后，迷走神经胃、肝、胰支活性降低。ANP的应用也引起肾上腺和肾交感神经传出活动的抑制。这些物质的最小有效剂量为100pg。在脱臭的制剂中，这些物质的施用后，没有观察到传出活性的变化。结果表明，释放到静脉循环中的五胃泌素、CCK-8、生长抑素和ANP等神经肽可通过血脑屏障不足的下丘脑神经元网络调节自主神经外流。

项目成果

Nakabayashi,H.: Neurosci.Lett.67. 78-81 (1986)

Nakabayashi,H.：神经科学快报67。

Niijima,A.: neurosci.Res.Suppl.3. S22 (1986)

Niijima,A.：neurosci.Res.Suppl.3。

Niijima,A.: Symposium on transcuction and cellular mechanisms in sensory receptors.Abstracts. (1986)

Niijima,A.：感觉受体转导和细胞机制研讨会。摘要。

Niijima, A.: "The effect of gastrin and cck on the efferent discharges of autonomic nerves." Neurosci. Res.Suppl. 3. s22 (1986)

Niijima, A.：“胃泌素和 cck 对自主神经传出放电的影响。”

Niijima,A.: J.Physiol.Soc.Jpn.49. 314 (1987)

Niijima,A.：J.Physiol.Soc.Jpn.49。