ROLE OF BRADYKININ IN THE REGULATION OF BLOOD PRESSURE AND RENAL HEMODYNAMICS.

缓激肽在血压和肾血流动力学调节中的作用。

基本信息

  • 批准号:
    62570377
  • 负责人:
  • 金额:
    $ 1.22万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1987
  • 资助国家:
    日本
  • 起止时间:
    1987 至 1989
  • 项目状态:
    已结题

项目摘要

To examine a possible role of endogenous bradykinin in the regulation of blood pressure(BP) and renal blood flow(RBF), a competitive antagonist of bradykinin(B4147) was studied in anesthetized Sprague Dawley(SD) rats, spontaneously hypertensive rats(SHR), DOCA salt hypertensive rats and Japanese albino rabbits. In SD rats, the intravenous infusion of B4147 inhibited the depressor effect of exogenous bradykinin by 69%. After an injection of B4147 at a dose of 25-100 mug in SD rats, BP increased and RBF decreased in a dose dependent fashion. The increase in BP was not blocked by treatment with angiotensin 11 antagonist or alpha_1-blocker. The administration of captopril decreased BP significantly. However, the injection of B4147 after the administration of captopril elicited an increase in BP of 43% of the initial decrease induced by captopril. These results suggest that the effects of B4147 on BP and RBF are not mediated through angiotensin 11 or sympathetic alpha_1-stimulation. Exogeno … More us bradykinin could contribute to the maintenance of BP and RBF in SD rats. Furthermore, bradykinin may partly participate in the acute hypotensive effect induced by the converting enzyme inhibitor captopril. In SHR, the magnitude in the change in BP was significantly lower in SHR than in control(WKY). The reduction of RBF was greater in WKY than in SHR. Bradykinin contributes to the maintenance of BP and RBF in both strains. However, deficiency in the bradykinin system in SHR may contributes partly to the development or the maintenance of hypertension. In DOCA-hypertensive rats, the magnitude of the increase in BP was significantly lower in DOCA hypertensive rats. The extent of the fall in RBF was reduced in DOCA hypertensive rats compared with control. These results suggest that endogenous bradykinin is depressed in the established phase of hypertension in DOCA-hypertensive rats. After the administration of bradykinin antagonist into the renal artery in anesthetized rabbits, both RBF and GFR were decreased significantly. These results indicate that endogenous kinins may participate in the regulation of RBF and GFR. Less
为探讨内源性缓激肽在血压(BP)和肾血流量(RBF)调节中的可能作用,在麻醉的SD大鼠、自发性高血压大鼠(SHR)、DOCA盐高血压大鼠和日本白化病上研究了缓激肽的竞争性拮抗剂B4147。在SD大鼠,静脉注射B4147可抑制外源性缓激肽的降压作用69%。在SD大鼠中以25-100 μ g的剂量注射B4147后,BP以剂量依赖性方式升高,RBF以剂量依赖性方式降低。用血管紧张素11拮抗剂或α_1受体阻滞剂治疗血压升高不被阻断。服用卡托普利后血压明显下降。然而,在给予卡托普利后注射B4147引起的血压升高是由卡托普利引起的初始降低的43%。这些结果表明,B4147对BP和RBF的作用不是通过血管紧张素11或交感神经α_1刺激介导的。外源基因 ...更多信息 缓激肽对SD大鼠血压和RBF有维持作用。缓激肽可能部分参与了转换酶抑制剂卡托普利的急性水肿作用。在SHR中,血压变化的幅度在SHR中显著低于对照组(WKY)。WKY的RBF下降幅度大于SHR。缓激肽有助于维持BP和RBF在这两个菌株。然而,缓激肽系统在SHR中的缺陷可能部分地参与了高血压的发展或维持。在DOCA-高血压大鼠中,DOCA高血压大鼠的BP增加幅度显著较低。与对照组相比,DOCA高血压大鼠RBF下降的程度降低。这些结果表明,内源性缓激肽在DOCA-高血压大鼠的高血压建立阶段被抑制。麻醉家兔肾动脉注射缓激肽拮抗剂后,RBF和GFR均显著降低。这些结果表明,内源性激肽可能参与调节RBF和GFR。少

项目成果

期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
清野正英ら: "アンジオテンシン変換酵素阻害剤の降圧作用におけるブラジキニンの関与" 医学のあゆみ. 146. 234-244 (1988)
Masahide Kiyono 等人:“缓激肽参与血管紧张素转换酶抑制剂的抗高血压作用”《医学史》146. 234-244 (1988)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Seino,M.et al.: "Effect of bradykinin antagonist on renal hemodynamics in anesthetized rabbits." J.Hypertension.
Seino,M.等人:“缓激肽拮抗剂对麻醉兔肾血流动力学的影响。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Seino, M. et al.: "Role of bradykinin in the regulation of blood pressure and renal blood flow in DOCA-salt hypertensive rats." J. Hypert. 8: 1990.
Seino, M. 等人:“缓激肽在 DOCA 盐高血压大鼠血压和肾血流调节中的作用。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Seino, M. et al.: "Effect of a bradykinin antagonist on renal hemodynamics in anesthetized rabbits." J. Hypert. 1990.
Seino, M. 等人:“缓激肽拮抗剂对麻醉兔子肾血流动力学的影响。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Seino,M.: "Role of bradykinin in the regulation of blood pressure and renal blood flow in DOCA-salt hypertensive rats." J.Hypertension.8. (1990)
Seino,M.:“缓激肽在 DOCA 盐高血压大鼠血压和肾血流调节中的作用。”
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SEINO Masahide其他文献

SEINO Masahide的其他文献

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