A comparative study of the laser-tissue interaction between solid state 213nm vs excimer gas 193nm laser systems

我们将对激光视力矫正手术的最新技术发展进行比较研究。我们将比较工作在213 nm的新型固体激光器和工作在193 nm的传统准分子气体激光器的生物效应。对于每种激光类型，将在相关的体内和体外动物模型中研究长期瘢痕形成、细胞毒性、诱变性和自由基产生。此外，优化固体激光器的辐照方案将导致广泛的生物应用的发展。

We will carry out a comparative study of the latest technological developments in laser vision correction surgery. We will compare the biological effects of a new solid state laser operating at 213nm and a traditional excimer gas laser operating at 193nm. For each laser type, long-term scarring, cytotoxicity, mutagenicity and free radical production will be studied in relevant in vivo and in vitro animal models. Furthermore, optimization of the irradiation protocol for the solid state laser will lead to the development of a wide range of biological applications.