Effect of lithium on the drug-induced excitation in animals

研究了-苯乙胺和苯乙胺- n -甲基转移酶（PNMT）抑制剂的作用方式。单剂量-苯乙胺对wistar大鼠产生兴奋作用。长期服用-苯乙胺也会使这一品系的大鼠产生多动症。测定大鼠纹状体中二羟基苯乙酸（DOPAC）和高香草酸（HVA）含量。长期给药后，DOPAC含量降低，HVA含量升高。^3H-spiperone结合位点和^3H mazindol结合位点没有显著变化。PNMT抑制剂SKF 64139在自发性高血压大鼠（SHR）、F344大鼠（F344）和Wistar大鼠中产生高活性。这些结果表明，大脑中多巴胺和肾上腺素含量的变化产生了大鼠的兴奋。锂治疗躁狂抑郁症的有效性是众所周知的。研究了长期给锂对小鼠-苯乙胺致多动症的影响。长期给药锂不能抑制-苯乙胺诱导的小鼠多动症，但可以防止多动症后的小鼠多动症。这一结果提示锂对躁狂抑郁症的预防作用。

The mode of action of -phenylethylamine and phenylethylamine-N-methyltransferase (PNMT) inhibitor was investigated. The single dose of -phenylethylamine produced the excitation in wistar rats. The chronic administration of -phenylethylamine also produced the hyperactivity in this strain of rats. Dihydroxyphyenylacetic acid (DOPAC) and homovanillic acid(HVA) were measured in the striatum of rats. DOPAC contents were decreased and HVA contents were increase after the chronic administration of -phenylethylamine. ^3H-spiperone binding sites and ^3H mazindol binding sites were not remarkably changed.SKF 64139, a PNMT inhibitor, produced the hyperactivity in spontaneously hypertensive rats(SHR), Fescher 344 rats(F344), and Wistar rats. These results suggest that the changes in dopamine and adrenaline contents in the brain produced the excitation in rats.The efficiency of lithium in manic depressive disorders is well known. The effect of chronic lithium administration on -phenylethylamine incuecd hyperactivity in mice was investigated. The chronic administration of lithium did not suppress the -phenylethylamine induced hyperactivity, but prevented the hypoactivity following after the hyperactivity in mice. This result suggests the prophylactic effect of lithium in manic depressive disorders.