Effect of lithium on the drug-induced excitation in animals

锂对动物药物诱导兴奋的影响

• 批准号: 62570486
• 负责人: KARIYA Tetsuhiko
• 金额: $ 1.02万
• 依托单位: Yamanashi Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570486/
• 关键词: -phenylethylamine; PNMT inhibitor; lithium; dopamine metabolism; 多動状態; ラットの種属差; βフエニルエチルアミン; 常同行動; ラット線条件

The mode of action of -phenylethylamine and phenylethylamine-N-methyltransferase (PNMT) inhibitor was investigated. The single dose of -phenylethylamine produced the excitation in wistar rats. The chronic administration of -phenylethylamine also produced the hyperactivity in this strain of rats. Dihydroxyphyenylacetic acid (DOPAC) and homovanillic acid(HVA) were measured in the striatum of rats. DOPAC contents were decreased and HVA contents were increase after the chronic administration of -phenylethylamine. ^3H-spiperone binding sites and ^3H mazindol binding sites were not remarkably changed.SKF 64139, a PNMT inhibitor, produced the hyperactivity in spontaneously hypertensive rats(SHR), Fescher 344 rats(F344), and Wistar rats. These results suggest that the changes in dopamine and adrenaline contents in the brain produced the excitation in rats.The efficiency of lithium in manic depressive disorders is well known. The effect of chronic lithium administration on -phenylethylamine incuecd hyperactivity in mice was investigated. The chronic administration of lithium did not suppress the -phenylethylamine induced hyperactivity, but prevented the hypoactivity following after the hyperactivity in mice. This result suggests the prophylactic effect of lithium in manic depressive disorders.

研究了苯乙胺和苯乙胺-N-甲基转移酶(PNMT)抑制剂的作用方式。单剂量-苯乙胺对Wistar大鼠产生兴奋作用。长期服用-苯乙胺也在这种品系的大鼠中产生了过度活动。测定大鼠纹状体中的二羟基苯乙酸(DOPAC)和高香草酸(HVA)。慢性给予苯乙胺后，DOPAC含量降低，HVA含量升高。在自发性高血压大鼠(SHR)、Fescher 344大鼠(F344)和Wistar大鼠(Wistar)中，3 H-螺环酮结合位点数和3 H-马吲哚结合位点数均无明显变化。这些结果表明，大脑中多巴胺和肾上腺素含量的变化导致了大鼠的兴奋。锂对躁狂抑郁障碍的疗效是众所周知的。本文研究了慢性给锂对苯乙胺所致小鼠活动亢进的影响。长期给锂不能抑制-苯乙胺引起的小鼠多动，但能预防小鼠多动后的低活动。这一结果提示锂在躁狂抑郁障碍中具有预防作用。

项目成果

Kariya,T.; Takahashi,Y.: Manic-depressive psychosis (Illustrated Handbook of Psychiatry). Medical View Ltd., 37-71 (1988)

刈谷，T.；

中河原通夫, 猪川和興, 本橋伸高, 渡辺明子, 朝田隆, 小野桂子, 渡辺ちさと, 假屋哲彦: 第18回日本神経精神薬理学会年会発表要旨集. 80 (1987)

Michio Nakakawara、Kazuoki Inokawa、Nobutaka Motohashi、Akiko Watanabe、Takashi Asada、Keiko Ono、Chisato Watanabe、Tetsuhiko Kariya：日本神经精神药理学会第 18 届年会摘要 80 (1987)。

本橋伸高,猪川和興,中河原通夫,朝田隆,假屋哲彦: 精神薬療基金研究年報. 19. 138-143 (1988)

Nobutaka Motohashi、Kazuoki Inokawa、Michio Nakakawara、Takashi Asada、Tetsuhiko Kariya：精神药物治疗基金年度报告 19. 138-143 (1988)。

Nakagawara,M;Kariya,T.;Asada,T.;Atobe,M.;Kubota,M.;Motohashi,N.: Psychopharmacology. Supplement96. 96 (1988)

Nakakawara，M；Kariya，T.；Asada，T.；Atobe，M.；Kubota，M.；Motohashi，N.：精神药理学。

小野桂子, 中河原通夫, 小原喜代三, 渡辺ちさと, 本橋伸高, 猪川和興, 朝田隆, 假屋哲彦: 薬物・精神・行動. 7. 81-82 (1987)

Keiko Ono、Michio Nakakawara、Kiyozo Ohara、Chisato Watanabe、Nobutaka Motohashi、Kazuoki Inokawa、Takashi Asada、Tetsuhiko Kariya：药物、精神病学和行为。7. 81-82 (1987)。