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Essential Trace Element in the Surgical Digestive Organ Disease - Digestive Malignant Disease and Selenium Metabolism

外科消化器官疾病中必需的微量元素——消化系统恶性肿瘤与硒代谢

基本信息

批准号：
62570621
负责人：
YAMAMURA Manabu
金额：
$ 0.51万
依托单位：
Kansai Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

We investigated the correlation of the selenium metabolism and the clinical stage in gastrointestinal cancer patients, and the inhibitory effect of selenium against pancreatic cancer in Syrian golden hamster induced by N'- nitrosobis(2-oxopropyl)amine. In clinical research, we found significantly lower selenium level both in the serum and in the tissue of the patients suffering from cancer comparing to those from the benign patients. The serum selenium level showed lower according to the progression of cancer stage, but the tissue selenium level showed no correlation with cancer stage. In animal research, 4-week-old female Syrian golden hamsters were divided into 2 groups according to the selenium level contained in the drinking water, 0.1ppm and 4.0ppm respectively and fed with the very low selenium purified diet. At 4 weeks after the commencement, some of the animals were begun to besusubcutaneously administered 10mg/kg body weight weekly 10 times, while the others were similarly administered saline alone. 18 weeks after the last injection, the hamsters were killed for histological examination and serum assays of selenium level and glutathione peroxidase activities. The number of the pancreatic cancer per a hamster was significantly inhibited in the high selenium group, in which the carcinogenests was also relatively inhibited. The selenium level and glutathione peroxidase activities of the serum revealed significantly higher in the high selenium group. These suggest the low selenium state could be a high risk factor for gastrointestinal cancer, and that the high selenium level is a preventive factor from cancer development, where glutathione peroxidase acts a role.

本文研究了胃肠道肿瘤患者硒代谢与临床分期的关系，以及硒对N '-亚硝基二（2-氧丙基）胺诱发的金黄地鼠胰腺癌的抑制作用。在临床研究中，我们发现癌症患者的血清和组织中的硒水平均显著低于良性疾病患者。血清硒水平随癌症分期的进展而降低，而组织硒水平与癌症分期无关。在动物实验中，将4周龄雌性叙利亚金黄地鼠按饮水含硒量分为0.1ppm和4.0ppm两组，分别饲喂极低硒纯饲料。开始后4周，部分动物开始以10 mg/kg体重的剂量每周给药10次，而另一些动物同样仅给予生理盐水。末次注射后18周处死仓鼠，进行组织学检查、血清硒水平和谷胱甘肽过氧化物酶活性测定。高硒组每只仓鼠的胰腺癌发生数明显受到抑制，致癌物也受到相对抑制。高硒组血清硒水平和谷胱甘肽过氧化物酶活性显著高于对照组。这表明低硒状态可能是胃肠道癌的高风险因素，高硒水平是癌症发展的预防因素，其中谷胱甘肽过氧化物酶起作用。