Right Ventricular Function in Retrograde Cardioplegia for Myocardial Protection : An Experimental Study

Mongrel狗被提交了这项研究，并被用一台传统的心脏-肺机器放置了一个心脏病旁路。总的空中交叉-所有狗的击球时间为60分钟。在第一组4 ° C圣托马斯医院的解决方案被注射到人工根的使用中。心脏病解决方案每20分钟都被重新使用一半的初始剂量。第二组中的狗在相同的解决方案中从日冕中提取了在60厘米高的滴水方法中提取的肾脏，以及重复剂量和间隔的Cardioplegia与第一组相同。第三组被用于治疗患有逆转性心脏病的狗，并结合使用冰壶进行主题冷却，在航空交叉曲柄60分钟后，心脏被重新启动。正确的肠道功能如心脏输出、正确的气压、正确的肠道内压、正确的肠道最大dp/dt，以及正确的肠道的短部分在心脏恢复后被测量了15、30、45和60分钟。在第二组中，正确的大气压力在心脏恢复后15至30分钟内显著升高。在另一方面，第三组显示的不必要变化的权利的所有基本功能的指标目前的实验研究演示了反向心脏病方法可以在心脏病恢复后产生的右静脉灌注在右静脉灌注早期的右静脉灌注结果。这一独特的影响可能是由与冰泥结合起来的对正确的文章的主题冷却的组合而产生的。

Mongrel dogs were subjected to this study and were placed on cardiopulmonary bypass using a conventional heart-lung machine. Total aortic cross-clamping time was 60 minutes in all dogs. In group I 4゜C St. Thomas' Hospital solution was injected into the aortic root by the use of a syringe. Cardioplegic solution was replenished every 20 minutes with a half of the initial dose. Group II were the dogs with the retrograde cardioplegia in which the same solution was given retrogradely from the coronary sinus by the drip method at the hight of 60cm, and the replenishing dose and interval of cardioplegia were the same as Group I. Group III was the dogs treated with retrograde cardioplegia identical to Group II and the combined use of topical cooling with ice-slush.The hearts were resuscitated after 60 minutes of aortic cross-clamping. Right ventricular functions such as cardiac output, right atrial pressure, right ventricular enddiastolic pressure, right ventricular max dp/dt, and shortening fraction of the right ventricle were measured 15, 30, 45, and 60 minutes after cardiac resuscitation respectively. In group II, right atrial pressure was significantly elevated from the control value 15 and 30 minutes after cardiac resuscitation. On the other hand, all indices of right ventricular function in Group III showed insignificant change. The present experimental study demonstrated the retrograde cardioplegic method could produce poor right ventricular perfusion resulting in right ventricular dystunction early after cardiac resuscitation. This deleterious effect however could be prevented by the combined sue of topical cooling of the right ventricle with ice-slush.