Experimental study of the whole body response in rabbits by linear acceleration and/or optokinetic stimulation

线性加速和/或视动刺激兔全身反应的实验研究

• 批准号: 62570782
• 负责人: MATSUNAGA Takashi
• 金额: $ 1.73万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570782/
• 关键词: rabbit; the whole body response; linear acceleration; optokinetic stimulation; sensory conflict; labyrinthectomy; parasympathetic nerve; motion sickness; 視覚刺激; 心拍数; 変動係数; アドレナリン; 遊離脂肪酸; 対軸方向刺激; 血糖

To study neural mechanisms of motion sickness in rabbits, we examined the physiological and biochemical body responses by several kinds of vestibule-visual conflict (VVC) stimulation (Type 1, Type 2a, Type 2b) for 300sec. Vestibular stimulation (VES) was linear oscillatory acceleration (amplitude:50cm, frequency:0.29Hz or 0.14Hz, direction: X=longitudinal, Y=transverse, Z=vertical) and visual stimulation (VIS) was optokinetic stimulation (random dot pattern drum with uniform velocity). Type 1 VVC stimulation was VES with VIS, Type 2a was VES without visual input and Type 2b was VIS only. Main results were as follows; 1. Heart rates (HR) decreased and coefficient of variation of R-R interval (CV-RR) increased during longitudinal Type 2a. And after atropine injection or bilateral labyrinthectomy, the changes of HR and CV-RR vanished. 2. Whole body responses during Type 2b were smaller than during Type 2a. 3. On body responses during Type 1, there was much difference between each rabbit. These results suggested that the extent of body responses differred by type of VVC stimulation, and in particular linear acceleration affected vestibule-autonomic reflex probably otolith-parasympathetic nerve reflex. Our results that the change of body responses decreased if VVC stimulation dissolved supported sensory conflict theory.

为了研究兔运动病的神经机制，我们检测了几种不同类型的前庭-视觉冲突(VVC)刺激(类型1、类型2a、类型2b)300秒时的生理和生化身体反应。前庭刺激(VES)为直线振荡加速度(幅度：50 cm，频率：0.29或0.14 Hz，方向：X=纵向，Y=横向，Z=垂直)，视觉刺激(VIS)为视动刺激(匀速随机点阵鼓)。VVC刺激类型1为VES+VIS，类型2a为无视觉输入的VES，类型2b为VIS。主要结果如下：1.纵向2a型心率(HR)降低，R-R间期变异系数(CV-RR)增大。注射阿托品或双侧迷路切除后，HR和CV-RR的变化消失。2.2b型的全身反应小于2a型。3.在类型1的身体反应上，每只兔之间存在较大差异。这些结果提示，刺激VVC的类型不同，身体反应的程度也不同，特别是线加速度影响前庭-自主神经反射，可能是耳石-副交感神经反射。我们的结果是，如果VVC刺激消失，身体反应的变化就会减少，这支持了感觉冲突理论。

项目成果

Wada Y. et al.: "Experimental study of the whole body response in rabbits by linear oscillatory stimulation (1)" Ear Res Jpn 19, 1988 : 450-452.

Wada Y.等人：“线性振动刺激对兔子全身反应的实验研究(1)”Ear Res Jpn 19，1988：450-452。

Wada Y. et al.: "Experimental study of the whole body response in rabbits by linear oscillatory stimulation (3)" Ear Res Jpn 21, 1990.

Wada Y. 等人：“线性振荡刺激对兔子全身反应的实验研究 (3)”Ear Res Jpn 21，1990。

和田佳郎: "家兎の直線加速度刺激に対する生体反応の実験的研究(1)" Ear Research Japan. 19. 450-452 (1988)

和田芳郎：“家兔对线性加速刺激的生物反应的实验研究（1）”日本耳朵研究19。450-452（1988）。