Clinical Application of Dipole Tracing Method Estimating Electric Generator Source in the Brain.

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Using the Dipole Tracing System, which we have developed and is non-invasive method to estimate electrical sources in the human brain from conventional EEG recordings, we have performed research works on three patients suffering from intractable epileptic seizure in University Hospital Uppsala, Sweden. The following findings were obtained from the research works.We have estimated dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head model were compared to MRI scans, the majority of the sharp wave dipoles were found to be located in the right hippocampal area. Previous long-term subdural recording had shown seizure onset in this area. These findings will be published in Neuroscience Letters in 1990.We have obtained correction factors from three-dimensional X-ray images of the subdural electrodes and estimated locations of the dipoles artificially elicited on the subdural electrodes. These findings will be published in IEEE Transaction of Biomedical Engineering in 1990.