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Simulation Test of Hemolysis by Micro-dye-Capsule Solution in a Centrifugal Blood Pump.

离心血泵中微染料胶囊溶液溶血的模拟试验。

基本信息

批准号：
01850042
负责人：
AKAMATSU Teruaki
金额：
$ 2.5万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B).
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01850042/
关键词：
Centrifugal blood pump.Hemolysis test Micro-capsule Pump performance

项目摘要

Hemolysis and coagulation of blood as well as dynamical pump performance are serious problems in blood pumps. It is specially important to develop a centrifugal blood pump with low hemolysis even under high speed rotation of impeller. Highly repeatable hemolysis test by real blood is not easy owing to biological surface reaction on materials. Therefore, if we, as substitute of red blood cell, use micro-dye-capsules, which are sensitive to dynamical forces but biologically inert, then we can expect highly repeatable hemolysis data only caused by pure dynamical effects. These capsules are particles for pressure sensing sheets of industrial use.The test results are as follows : "1". We established simulation test methods of hemolysis with micro-dye -capsule solutions (produced by Fuji Film Inc.). The leuco dye in the damaged capsule becomes free as droplets in the solutions. Measured dye concentration on a color sensing sheet indicates thedamaged grade of the capsules. This is very similar to free hemoglobin in real hemolysis test. "2". Hemolysis tests of in double cones and nutating centrifugal blood pumps result that the damage of capsules is expressible with an exponential function of shear stress multiplied by elapse time. The damage of capsules increase severely at the higher rotational speed than 3500 rpm. The threshold of hemolysis for our nutating centrifugal pump proved to be 3500 rpm. This correlate well with hemolysis test by real blood.

血液的溶血和凝血以及动力泵的性能是血泵面临的严重问题。因此，研制一种即使在叶轮高速旋转下也能保持低溶血性的离心式血泵显得尤为重要。由于材料上的生物表面反应，用真实血液进行高度重复性的溶血试验并非易事。因此，如果我们作为红细胞的替代品，使用对动力敏感但生物惰性的微染料胶囊，那么我们可以预期只由纯动力效应引起的高度重复性的溶血数据。这些胶囊是用于工业压力传感片材的颗粒。测试结果如下：“1”。我们建立了微染胶囊液(富士胶片公司生产)的溶血模拟试验方法。受损胶囊中的无色染料变成溶液中的液滴。在感色板上测量的染料浓度表明了胶囊的损坏程度。这与实际溶血试验中的游离血红蛋白非常相似。“2”。双锥体和螺纹式离心泵的溶血试验结果表明，胶囊的损伤可用剪应力乘以时间的指数函数表示。当转速高于3500rpm时，胶囊损伤严重。我们研制的螺杆离心泵的溶血阈值为3500转/分。这与真实血液的溶血试验有很好的相关性。