Isozymic Changes in Myosin of the Cardiac Ventricular Myocardium induced by the Sympathetic Nerve.

交感神经诱导的心室心肌肌球蛋白的同工酶变化。

• 批准号: 63570414
• 负责人: KIMATA Shin-ichi
• 金额: $ 1.47万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570414/
• 关键词: Sympathetic nerve; Catecholamine; Myosin isozyme; SR Ca^<++> ATPase; Heart failure; 心不全; 心肥大; ミオシン

(1) Isozymic changes in myosin of rabbit ventricular myocardium induced by the sympathetic nerve.Cardiac myosin has two isozymes alpha and beta. alpha-myosin has high ATPase activity and its contraction is rapid but the energy efficiency is poor. On the other hand, beta-myosin has low ATPase activity, and its contraction is slow but the energy efficiency is good. After complete denervation of the sympathetic nerves, alpha myosin disappeared and was replaced by beta myosin in the cardiac ventricle. By beta sympathetic nervous receptor stimulated with isoproterenal, alpha myosin decreased and beta myosin increased.(2) Isozymic changes in myosin of the ventricular myocardium in patients with congestive heart failure.There was a good correlation between the ratio of alpha myosin and the dosage of catecholamine administered in the last stage. In the heart of human beings, also, alpha myosin was increased by catecholamine.

(1)交感神经诱导兔心室心肌肌球蛋白的同工酶变化。心肌肌凝蛋白有两种同工酶。肌球蛋白atp酶活性高，收缩快，但能量效率较差。另一方面，-肌球蛋白的atp酶活性较低，收缩缓慢，但能量效率较好。交感神经完全去支配后，心室内α肌球蛋白消失，代之以β肌球蛋白。异丙肾上腺素刺激-交感神经受体后，-肌球蛋白降低，-肌球蛋白升高。(2)充血性心力衰竭患者心肌肌球蛋白的同工酶变化。肌球蛋白的比值与晚期给药儿茶酚胺的剂量有良好的相关性。在人类的心脏中，儿茶酚胺也增加了肌球蛋白。

项目成果

Kawana M, Kimata S et al: "Myosin isozyme distribution in normal and overload human Heart-An immunohistochemucal study using monoclonal antibodies." Theraperitic Research. 7. 45-51 (1987)

Kawana M、Kimata S 等人：“正常和超负荷人类心脏中的肌球蛋白同工酶分布 - 使用单克隆抗体的免疫组织化学研究。”

Tsuchimochi H, Kawana M, Kimata S et al: "Expression of interleukin 1 in DCM hearts." Jap. Circul. J.53. 522 (1990)

Tsuchimochi H、Kawana M、Kimata S 等人：“DCM 心脏中白细胞介素 1 的表达”。

Ishizuka N, Kawana M, Taira A, Kimata S et al: "Isozymic changes in myosin of rabbit ventricular myocardium induced by isoproterenol." Jap. Circul. J.53. 905 (1989)

Ishizuka N、Kawana M、Taira A、Kimata S 等人：“异丙肾上腺素诱导的兔心室心肌肌球蛋白的同工酶变化。”

石塚 尚子: "正常心および病的心におけるヒト心筋ミオシンアイソザイムの分布" 東女医大誌. 57. 1557-1566 (1987)

Naoko Ishizuka：“正常和病理心脏中人类心肌肌球蛋白同工酶的分布”东京女子医科大学学报 57. 1557-1566 (1987)。

Isizuka N: "Isozymic changes in myosin of human ventricular myocardium." J. Tokyo Women's Medical College. 57. 1557-1566 (1987)

Isizuka N：“人心室心肌肌球蛋白的同工酶变化。”