Studies on surgical treatment for esophageal carcinoma based on biological characteristics of the cancer cell and immunological response of the patients.

基于癌细胞生物学特性和患者免疫反应的食管癌手术治疗研究。

• 批准号: 63570654
• 负责人: YAMANA Hideaki
• 金额: $ 1.34万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570654/
• 关键词: Esophageal carcinoma; Biological characteristics; Host defence phenomenon; DNA histogram; Monoclonal antibody; Proliferating cells; Glycolipids; グライフリピッド; 生体防御反能; モノクローナル抗体; 殺細胞効果

Biological characteristics and immnologic response of esophageal carcinoma were studied clinically and experimentally. DNA contents of the cancer cell nuclear were measured by flow cytometry. From this study, aneuploid cancer showed significant poor survival as compared to diploid one. But there were no significances in patients with radical operation except early cancers between diploid and aneuploid cancers. Proliferating cancer cells were measured by monoclonal antibody Ki-67. By this result, the cancer with Ki-67 positive cells showed significant poor prognosis as compared to the cancer without Ki-67 positive cells. Monoclonal antibody of KISM-1 which was produced in our Institute showed high affinity to esophageal squamous cell carcinoma, and a low affinity was recognized in stomach and colonic carcinoma.

本文对食管癌的生物学特性和免疫学反应进行了临床和实验研究。流式细胞仪检测癌细胞核DNA含量。从这项研究来看，与二倍体癌症相比，非整倍体癌症显示出显著较差的存活率。但在根治性手术患者中，除早期癌外，二倍体与异倍体癌之间无显著性差异。用单克隆抗体Ki-67检测癌细胞增殖。根据该结果，与没有Ki-67阳性细胞的癌症相比，具有Ki-67阳性细胞的癌症显示出显著的不良预后。本研究所制备的KISM-1单克隆抗体对食管鳞癌有较高的亲和力，而对胃、结肠癌的亲和力较低。

项目成果

白水玄山: "食道癌における生物学的悪性度ーー最近の研究から" 腫瘍と感染. 1. 1-5 (1988)

Genzan Shiramizu：“食道癌的生物恶性肿瘤 - 来自最近的研究”肿瘤和感染。

白水玄山: 腫瘍と感染. 1. 1-5 (1988)

Genzan Hakusui：肿瘤和感染。1. 1-5 (1988)

力武浩: "食道癌細胞の悪性度と生体反応" フロ-サイトメトリ-. 7. 124-128 (1988)

Hiroshi Rikitake：“食管癌细胞的恶性和生物反应”流式细胞术。7. 124-128 (1988)。

Rikitake H.: "Malignant potential and immunologic reaction in esophageal cancer" Flowcytometry 7:124-128, 1988.

Rikitake H.：“食道癌的恶性潜能和免疫反应”流式细胞术 7：124-128，1988。

掛川暉夫: 現代医療. 20. 2157-2161 (1988)

挂川昭夫：现代医学。20。2157-2161（1988）