Studies on surgical treatment for esophageal carcinoma based on biological characteristics of the cancer cell and immunological response of the patients.

对食道癌的生物学特性和免疫反应进行了临床和实验研究。用流式细胞仪检测癌细胞细胞核DNA含量。在这项研究中，与二倍体癌症相比，非整倍体癌症的存活率明显较低。而在根治性手术患者中，除早期癌外，二倍体与非整倍体癌之间差异无统计学意义。用单克隆抗体Ki-67检测增殖的癌细胞。由此可见，Ki-67阳性细胞癌的预后明显差于无Ki-67阳性细胞癌。本研究所研制的KISM-1单抗对食管鳞癌具有较高的亲和力，而在胃和结肠癌中亲和力较低。

Biological characteristics and immnologic response of esophageal carcinoma were studied clinically and experimentally. DNA contents of the cancer cell nuclear were measured by flow cytometry. From this study, aneuploid cancer showed significant poor survival as compared to diploid one. But there were no significances in patients with radical operation except early cancers between diploid and aneuploid cancers. Proliferating cancer cells were measured by monoclonal antibody Ki-67. By this result, the cancer with Ki-67 positive cells showed significant poor prognosis as compared to the cancer without Ki-67 positive cells. Monoclonal antibody of KISM-1 which was produced in our Institute showed high affinity to esophageal squamous cell carcinoma, and a low affinity was recognized in stomach and colonic carcinoma.