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PATHOGENESIS OF LUMBAR NERVE ROOTS UNDER CHRONIC COMPRESSION

慢性压迫下腰神经根的发病机制

基本信息

批准号：
63570700
负责人：
TAGUCHI Toshihiko
金额：
$ 1.34万
依托单位：
YAMAGUCHI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570700/
关键词：
Spinal nerve root Root symptom Anatomy Lumber spine 坐骨神経痛

项目摘要

Rabbits have been selected in several spine studies as they are easier to obtain and keep. However,an appreciation of difference in structural is essential for the correct extrapolation of results in the human situation. For the purpose of this, we studied comparison of the human and rabbit spinal nerve root by means of light microscope,electron microscopy.The main results found were as follows; (1) The structure of the connective tissue of spinal nerve roots in the human and rabbits were essentially same. The epineurium became continuous with dura mater in the subarachnoid angle. The outer perineural layers left the nerve and passed away from it between the dura and arachnoid and the inner layers of perineurium continued with the nerve root sheeth.The nerve root sheeth could be divided into two basic layers. The cells in the outer layers were arranged loosely and in the inner layers were regularly arranged and close to each other. (2) However,there were a few difference between them. i) Spinal ganglion of rabbits were closer to spinal cord. ii) In rabbits,arachnoid and root sheeth were thinner and arachnoid villi were underdeveloped. iii) Subarachnoid space of rabbits was narrower.And,we also did experimental study to observe microvasculature in spinal nerve roots using polyester resin (MercoxCL-2B). This result showed the spinal nerve root is similar to peripheral nerve root in microvasculature which is very abundant and developed. We could not find out water shed which Parke reported. From these observation, there is possibility that spinal nerve roots derived nutrients not only from the microvascular system but also from cerebrospinal fluid.

在几项脊柱研究中选择了兔子，因为它们更容易获得和饲养。然而，对结构差异的认识对于正确推断人类状况的结果是必不可少的。为此，我们采用光镜、电镜对人和家兔脊神经根进行了比较研究。主要研究结果如下：(1)人和家兔脊神经根结缔组织结构基本相同。神经外膜在蛛网膜下角与硬脑膜连续。外会神经层离开神经并在硬脑膜和蛛网膜之间离开神经会神经层的内层与神经根鞘相连。神经根鞘可分为两层。外层细胞排列松散，内层细胞排列规则，排列紧密。然而，他们之间有一些不同之处。i)家兔的脊髓神经节离脊髓更近。ii)家兔蛛网膜和根鞘变薄，蛛网膜绒毛发育不全。iii)家兔蛛网膜下腔变窄。同时，我们用聚酯树脂（MercoxCL-2B）对脊髓神经根的微血管进行了实验研究。结果表明，脊神经根与周围神经根相似，微血管非常丰富和发达。我们找不到帕克报告的分水岭。从这些观察结果来看，脊神经根可能不仅从微血管系统中获取营养，而且从脑脊液中获取营养。