Atrial Natriuretic Peptide (ANP) in Childhood

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(1) To investigate the ANP levels in congenital heart disease, we measured plasma ANP in 29 patients, with left-to-right shunt, and right auricle ANP in 25 patients who underwent operation. The levels of ANP in the pulmonary artery correlated with mean pulmonary arterial pressure. The right auricle ANP levels was high in patients with heart failure combined with pressure or volume overload of the right atrium. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac disease.(2) To determine the molecular forms of ANP in patients with cardiovascular disease, we analyzed the ANP content in the right atrium using reverse phase HPLC with RIA. In patients younger than 20 yr old, the major component was gamma-ANP. The differences in the content and molecular forms of ANP in atrial tissue reflect the pathological state in patients with cardiovascular diseases, as well as the patient's age.(3) ANP level was measured in plasma and atrium of monocrotaline induced pulmonary, hypertensive rats. Plasma ANP levels were elevated in PH rats, and tissue levels of ANP were lower than those in controls. Thus, development of pulmonary hypertension led to an increase in release of ANP from the right atrium.